Adipose-derived autotaxin regulates inflammation and steatosis associated with diet-induced obesity.
Adipocytes
/ metabolism
Adipose Tissue
/ metabolism
Adiposity
/ physiology
Animals
Diet, High-Fat
/ adverse effects
Dietary Fats
/ metabolism
Inflammation
/ metabolism
Lysophospholipids
/ metabolism
Mice
Mice, Inbred C57BL
Obesity
/ metabolism
Phosphoric Diester Hydrolases
/ metabolism
Triglycerides
/ metabolism
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2019
2019
Historique:
received:
12
06
2018
accepted:
12
11
2018
entrez:
8
2
2019
pubmed:
8
2
2019
medline:
30
10
2019
Statut:
epublish
Résumé
Autotaxin (ATX) is a secreted enzyme that generates the bioactive lipid lysophosphatidic acid (LPA). We generated mice with global inducible post-natal inactivation or adipose-specific loss of the Enpp2 gene encoding ATX. The animals are phenotypically unremarkable and exhibit differences in adipocyte size and adipose tissue expression of inflammatory genes after high fat feeding without gross differences in fat distribution or body mass. Surprisingly, both models of Enpp2- deficiency exhibited marked protection from high fat diet-induced hepatic steatosis. This phenotype was not associated with differences in dietary fat absorption but may be accounted for by differences in hepatic expression of genes involved in de novo synthesis of triglycerides. These findings suggest that pharmacological inhibition of ATX might be protective against hepatic steatosis.
Identifiants
pubmed: 30730895
doi: 10.1371/journal.pone.0208099
pii: PONE-D-18-17633
pmc: PMC6366870
doi:
Substances chimiques
Dietary Fats
0
Lysophospholipids
0
Triglycerides
0
Phosphoric Diester Hydrolases
EC 3.1.4.-
alkylglycerophosphoethanolamine phosphodiesterase
EC 3.1.4.39
lysophosphatidic acid
PG6M3969SG
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0208099Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM103527
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL120507
Pays : United States
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Am J Respir Cell Mol Biol. 2012 Nov;47(5):566-74
pubmed: 22744859
J Lipid Res. 2015 Jun;56(6):1134-44
pubmed: 25896349
JAMA. 2010 Jan 20;303(3):235-41
pubmed: 20071471
J Pharmacol Exp Ther. 2017 Jan;360(1):1-13
pubmed: 27754931
Cell Physiol Biochem. 2017;43(2):445-456
pubmed: 28922661
Diabetes. 2014 Dec;63(12):4154-64
pubmed: 24969110
Clin Chim Acta. 2011 Jun 11;412(13-14):1201-6
pubmed: 21419756
Anal Chem. 2018 Apr 3;90(7):4249-4257
pubmed: 29543437
J Biol Chem. 2006 Sep 1;281(35):25822-30
pubmed: 16829511
J Clin Invest. 2001 Jan;107(2):181-9
pubmed: 11160134
Prostaglandins Other Lipid Mediat. 2001 Apr;64(1-4):47-62
pubmed: 11324707
Nat Struct Mol Biol. 2011 Feb;18(2):198-204
pubmed: 21240271
J Biol Chem. 2003 May 16;278(20):18162-9
pubmed: 12642576
Diabetologia. 2005 Mar;48(3):569-77
pubmed: 15700135
Cell Metab. 2006 May;3(5):321-31
pubmed: 16679290
Gastroenterology. 2004 Jul;127(1):139-44
pubmed: 15236180
J Biol Chem. 2005 Apr 15;280(15):14656-62
pubmed: 15710620
J Immunol. 2008 Oct 1;181(7):5111-9
pubmed: 18802115
World J Gastroenterol. 2018 Sep 28;24(36):4132-4151
pubmed: 30271079
FASEB J. 2014 Feb;28(2):861-70
pubmed: 24277575
J Clin Invest. 1999 Jun;103(11):1489-98
pubmed: 10359558
Mol Endocrinol. 2012 May;26(5):786-97
pubmed: 22474126
Mol Cell Biol. 2006 Jul;26(13):5015-22
pubmed: 16782887
Br J Pharmacol. 2018 Feb;175(4):693-707
pubmed: 29197066
Metabolites. 2012 Feb 20;2(1):195-213
pubmed: 24957374
Annu Rev Nutr. 2010 Aug 21;30:173-99
pubmed: 20420526
J Exp Med. 2012 Dec 17;209(13):2339-50
pubmed: 23209312
Methods Mol Biol. 2012;821:421-33
pubmed: 22125082
FASEB J. 2015 Sep;29(9):3990-4000
pubmed: 26071407
Arch Physiol Biochem. 2008 Jul;114(3):183-94
pubmed: 18629684
J Exp Med. 2012 May 7;209(5):925-33
pubmed: 22493518
Am J Respir Crit Care Med. 2013 Oct 15;188(8):928-40
pubmed: 24050723
J Lipid Res. 2011 Jun;52(6):1247-55
pubmed: 21421848
JAMA. 2014 Jul;312(2):189-90
pubmed: 25005661
Blood. 2014 Nov 13;124(20):3141-50
pubmed: 25277122
J Biol Chem. 2011 Dec 23;286(51):43972-83
pubmed: 21971049
J Biol Chem. 2011 Oct 7;286(40):34654-63
pubmed: 21832043
Annu Rev Pharmacol Toxicol. 2010;50:157-86
pubmed: 20055701
PLoS One. 2010 Mar 17;5(3):e9741
pubmed: 20305819
J Lipid Res. 2017 Nov;58(11):2102-2113
pubmed: 28874440
J Physiol Biochem. 2012 Dec;68(4):635-44
pubmed: 22644624