Arylpyridines, arylpyrimidines and related compounds as potential modulator agents of the VEGF, hTERT and c-Myc oncogenes.
Antineoplastic Agents
/ chemical synthesis
Cell Line, Tumor
Cell Proliferation
/ drug effects
Down-Regulation
/ drug effects
Gene Expression
/ drug effects
HEK293 Cells
Humans
Protein Biosynthesis
/ drug effects
Proto-Oncogene Proteins c-myc
/ genetics
Pyridines
/ chemical synthesis
Pyrimidines
/ chemical synthesis
Telomerase
/ genetics
Vascular Endothelial Growth Factor A
/ genetics
Anticancer agents
Antiproliferative activity
Aza and diazabiphenyl derivatives
Gene targeting
Journal
Bioorganic & medicinal chemistry
ISSN: 1464-3391
Titre abrégé: Bioorg Med Chem
Pays: England
ID NLM: 9413298
Informations de publication
Date de publication:
01 03 2019
01 03 2019
Historique:
received:
07
11
2018
revised:
21
01
2019
accepted:
29
01
2019
pubmed:
9
2
2019
medline:
15
1
2020
entrez:
9
2
2019
Statut:
ppublish
Résumé
Twenty-four derivatives structurally related to honokiol have been synthesized and biologically evaluated. IC
Identifiants
pubmed: 30733086
pii: S0968-0896(18)31888-1
doi: 10.1016/j.bmc.2019.01.039
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
MYC protein, human
0
Proto-Oncogene Proteins c-myc
0
Pyridines
0
Pyrimidines
0
VEGFA protein, human
0
Vascular Endothelial Growth Factor A
0
TERT protein, human
EC 2.7.7.49
Telomerase
EC 2.7.7.49
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
880-887Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.