Genome-wide Approaches to Investigate Anthelmintic Resistance.
anthelmintic resistance
candidate genes
genome-wide association
genomics
parasitic helminths
Journal
Trends in parasitology
ISSN: 1471-5007
Titre abrégé: Trends Parasitol
Pays: England
ID NLM: 100966034
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
04
12
2018
revised:
08
01
2019
accepted:
08
01
2019
pubmed:
9
2
2019
medline:
23
4
2019
entrez:
9
2
2019
Statut:
ppublish
Résumé
The rapid evolution of anthelmintic resistance in a number of parasites of livestock and domesticated animals has occurred in response to widespread use of anthelmintics for parasite control, and threatens the success of parasite control of species that infect humans. The genetic basis of resistance to most anthelmintics remains poorly resolved. Genome-wide approaches are now accessible due to recent advances in high-throughput sequencing, and are increasingly applied to characterize traits including drug resistance. Here, we discuss why traditional candidate gene studies have largely failed to define the genetics of resistance, and why - and in what circumstances - we expect genome-wide approaches to shed new light on the modes of action and the evolution of resistance to anthelmintic compounds.
Identifiants
pubmed: 30733094
pii: S1471-4922(19)30016-9
doi: 10.1016/j.pt.2019.01.004
pii:
doi:
Substances chimiques
Anthelmintics
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
289-301Subventions
Organisme : Wellcome Trust
ID : 098051
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 206194
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/M003949/1
Pays : United Kingdom
Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.