Endophilin-A regulates presynaptic Ca
Acyltransferases
/ physiology
Animals
Calcium
/ metabolism
Cochlea
/ cytology
Endocytosis
Exocytosis
/ physiology
Female
Hair Cells, Auditory
/ cytology
Male
Membrane Proteins
/ metabolism
Mice
Mice, Inbred C57BL
Mice, Knockout
Presynaptic Terminals
/ physiology
Synapses
/ physiology
Synaptic Transmission
Synaptic Vesicles
/ physiology
electron microscopy
endocytosis
membrane capacitance
ribbon synapse
super‐resolution microscopy
Journal
The EMBO journal
ISSN: 1460-2075
Titre abrégé: EMBO J
Pays: England
ID NLM: 8208664
Informations de publication
Date de publication:
01 03 2019
01 03 2019
Historique:
received:
22
06
2018
revised:
17
12
2018
accepted:
20
12
2018
pubmed:
9
2
2019
medline:
7
1
2020
entrez:
9
2
2019
Statut:
ppublish
Résumé
Ribbon synapses of cochlear inner hair cells (IHCs) operate with high rates of neurotransmission; yet, the molecular regulation of synaptic vesicle (SV) recycling at these synapses remains poorly understood. Here, we studied the role of endophilins-A1-3, endocytic adaptors with curvature-sensing and curvature-generating properties, in mouse IHCs. Single-cell RT-PCR indicated the expression of endophilins-A1-3 in IHCs, and immunoblotting confirmed the presence of endophilin-A1 and endophilin-A2 in the cochlea. Patch-clamp recordings from endophilin-A-deficient IHCs revealed a reduction of Ca
Identifiants
pubmed: 30733243
pii: embj.2018100116
doi: 10.15252/embj.2018100116
pmc: PMC6396150
pii:
doi:
Substances chimiques
Membrane Proteins
0
otoferlin protein, mouse
0
Acyltransferases
EC 2.3.-
2-acylglycerophosphate acyltransferase
EC 2.3.1.52
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2019 The Authors.
Références
EMBO J. 2015 Nov 3;34(21):2686-702
pubmed: 26446278
Neuron. 2000 Aug;27(2):301-12
pubmed: 10985350
EMBO J. 2016 Dec 1;35(23):2536-2552
pubmed: 27458190
Annu Rev Neurosci. 2012;35:509-28
pubmed: 22715884
EMBO J. 2014 Feb 3;33(3):247-64
pubmed: 24442635
Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4483-8
pubmed: 19246382
Nat Commun. 2018 Jan 18;9(1):290
pubmed: 29348575
J Neurocytol. 1986 Jun;15(3):311-28
pubmed: 3746347
Cell. 2017 Jun 29;170(1):172-184.e11
pubmed: 28648660
J Neurosci. 2005 Dec 14;25(50):11577-85
pubmed: 16354915
Neuron. 1999 Sep;24(1):143-54
pubmed: 10677033
Cell. 2003 Oct 3;115(1):37-48
pubmed: 14532001
Pflugers Arch. 1988 Feb;411(2):137-46
pubmed: 3357753
Nature. 2015 Jan 22;517(7535):493-6
pubmed: 25517096
Nat Neurosci. 2009 Apr;12(4):444-53
pubmed: 19270686
Neuron. 2015 Feb 4;85(3):484-96
pubmed: 25654254
Front Cell Neurosci. 2018 Feb 06;12:27
pubmed: 29467622
J Biol Chem. 2009 Jan 16;284(3):1364-72
pubmed: 19004828
Dev Cell. 2009 Dec;17(6):811-22
pubmed: 20059951
Traffic. 2015 Mar;16(3):229-40
pubmed: 25346420
J Neurosci. 1982 Jul;2(7):942-57
pubmed: 7097321
J Clin Invest. 2012 Dec;122(12):4401-11
pubmed: 23187129
Neuron. 2001 Mar;29(3):681-90
pubmed: 11301027
Neuron. 2002 Nov 14;36(4):649-59
pubmed: 12441054
Cell. 2010 Oct 29;143(3):430-41
pubmed: 21029864
J Neurochem. 2007 Aug;102(3):931-43
pubmed: 17437541
Nat Rev Mol Cell Biol. 2012 Jan 11;13(2):75-88
pubmed: 22233676
Cell. 2006 Oct 20;127(2):277-89
pubmed: 17055430
Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19332-7
pubmed: 17158794
Cell Rep. 2016 Oct 18;17(4):1071-1086
pubmed: 27720640
J Neurosci. 2014 Jan 15;34(3):705-16
pubmed: 24431429
J Neurosci. 2016 Jan 20;36(3):649-54
pubmed: 26791198
Nat Neurosci. 2011 Apr;14(4):411-3
pubmed: 21378973
J Neurosci. 2011 Mar 30;31(13):4886-95
pubmed: 21451027
Nature. 2005 Apr 14;434(7035):889-94
pubmed: 15829963
Nat Neurosci. 2010 Jul;13(7):869-76
pubmed: 20562868
Brain Res. 1981 Aug;254(1):65-75
pubmed: 7272773
Hum Mol Genet. 2009 Dec 1;18(23):4615-28
pubmed: 19744958
J Cell Sci. 2011 Jan 1;124(Pt 1):133-43
pubmed: 21172823
Neuron. 1994 Oct;13(4):875-83
pubmed: 7946334
Hear Res. 1996 Apr;93(1-2):28-51
pubmed: 8735067
J Neurosci. 2013 May 29;33(22):9508-19
pubmed: 23719817
PLoS Genet. 2010 Aug 05;6(8):
pubmed: 20700442
Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):883-8
pubmed: 10639174
J Neurosci. 2013 Mar 6;33(10):4456-67
pubmed: 23467361
FEBS Lett. 2018 Nov;592(21):3633-3650
pubmed: 30251250
Cell Res. 2015 Apr;25(4):496-516
pubmed: 25771685
Cold Spring Harb Perspect Biol. 2012 Sep 01;4(9):a005645
pubmed: 22763746
Neuron. 2010 Nov 18;68(4):724-38
pubmed: 21092861
J Neurosci. 2009 Jun 24;29(25):7991-8004
pubmed: 19553439
EMBO J. 2016 Dec 1;35(23):2519-2535
pubmed: 27729456
Cell. 2000 Jul 7;102(1):89-97
pubmed: 10929716
PLoS Genet. 2009 May;5(5):e1000480
pubmed: 19424431
J Cell Sci. 2015 Feb 15;128(4):638-44
pubmed: 25609709
Cell Tissue Res. 2015 Jul;361(1):95-114
pubmed: 25874597
Cell. 2002 Apr 5;109(1):101-12
pubmed: 11955450
EMBO J. 2013 Oct 16;32(20):2722-34
pubmed: 24076656
J Cell Biol. 2014 May 26;205(4):591-606
pubmed: 24862576
Arch Otolaryngol. 1964 Oct;80:418-30
pubmed: 14198707
Neuron. 2003 Nov 13;40(4):733-48
pubmed: 14622578
Elife. 2015 Nov 14;4:
pubmed: 26568308
EMBO Rep. 2015 Feb;16(2):232-9
pubmed: 25520322
J Neurosci. 2014 May 14;34(20):6843-8
pubmed: 24828638
Neuron. 2014 Jun 4;82(5):981-8
pubmed: 24908483
Neuron. 2003 Nov 13;40(4):749-62
pubmed: 14622579
PLoS One. 2014 Feb 05;9(2):e88353
pubmed: 24505482
J Neurosci. 2003 Nov 26;23(34):10832-40
pubmed: 14645476
EMBO Rep. 2017 Nov;18(11):2015-2029
pubmed: 28893864
Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):E4716-25
pubmed: 27462107
Nat Rev Neurosci. 2011 Mar;12(3):127-38
pubmed: 21304549
Neuron. 2011 Nov 17;72(4):587-601
pubmed: 22099461
Neuron. 2018 Jun 27;98(6):1184-1197.e6
pubmed: 29953872