Dynamic Contrast-Enhanced MRI Reveals Unique Blood-Brain Barrier Permeability Characteristics in the Hippocampus in the Normal Brain.
Journal
AJNR. American journal of neuroradiology
ISSN: 1936-959X
Titre abrégé: AJNR Am J Neuroradiol
Pays: United States
ID NLM: 8003708
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
30
04
2018
accepted:
17
12
2018
pubmed:
9
2
2019
medline:
4
3
2020
entrez:
9
2
2019
Statut:
ppublish
Résumé
We report a prospective dynamic contrast-enhanced MR imaging analysis of region-specific blood-brain barrier permeability in 5 healthy subjects. By means of standardized postprocessing and ROI sampling methods, the hippocampi revealed significantly elevated area under the dynamic contrast-enhanced curve and significantly increased blood-brain barrier permeability metrics (volume transfer constant and volume in the extravascular extracellular space) from model-based quantitation. These findings suggest unique blood-brain barrier permeability characteristics in the hippocampus, which are concordant with previous animal studies, potentially laying the groundwork for future studies assessing patient populations in which hippocampal pathology plays a role.
Identifiants
pubmed: 30733256
pii: ajnr.A5962
doi: 10.3174/ajnr.A5962
pmc: PMC7028673
doi:
Substances chimiques
Contrast Media
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
408-411Subventions
Organisme : NIAID NIH HHS
ID : P01 AI073693
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
© 2019 by American Journal of Neuroradiology.
Références
Neuron. 2015 Jan 21;85(2):296-302
pubmed: 25611508
Learn Mem. 2011 Dec 16;19(1):15-25
pubmed: 22180053
Front Neurol Neurosci. 2014;34:18-25
pubmed: 24777127
AJNR Am J Neuroradiol. 2011 Dec;32(11):2047-53
pubmed: 21960495
Science. 1984 Sep 14;225(4667):1168-70
pubmed: 6474172
Neurobiol Aging. 2009 Nov;30(11):1818-24
pubmed: 18358568
J Cereb Blood Flow Metab. 2015 Nov;35(11):1836-45
pubmed: 26082014
Neuropathology. 2011 Jun;31(3):230-8
pubmed: 21092063
Arthritis Rheumatol. 2014 Dec;66(12):3387-94
pubmed: 25156222
Neurocrit Care. 2005;3(1):46-50
pubmed: 16159094
AJNR Am J Neuroradiol. 2016 Jul;37(7):1267-74
pubmed: 26965465
Brain Tumor Pathol. 2016 Apr;33(2):89-96
pubmed: 26920424
Psychiatr Ann. 2012 Sep;42(9):322-328
pubmed: 25620816
Front Aging Neurosci. 2010 Mar 30;2:12
pubmed: 20552050
Diagn Interv Imaging. 2013 Dec;94(12):1187-204
pubmed: 24211260
Brain. 2012 Oct;135(Pt 10):3039-50
pubmed: 23065792
Brain Res Mol Brain Res. 2005 Oct 31;140(1-2):120-6
pubmed: 16137784
Lupus Sci Med. 2015 Mar 28;2(1):e000074
pubmed: 25861456
Brain Res. 2003 Aug 29;982(2):260-9
pubmed: 12915260