Patterns of TIGIT Expression in Lymphatic Tissue, Inflammation, and Cancer.


Journal

Disease markers
ISSN: 1875-8630
Titre abrégé: Dis Markers
Pays: United States
ID NLM: 8604127

Informations de publication

Date de publication:
2019
Historique:
received: 27 07 2018
accepted: 18 10 2018
entrez: 9 2 2019
pubmed: 9 2 2019
medline: 30 5 2019
Statut: epublish

Résumé

TIGIT is an inhibitory immune checkpoint receptor and a putative target for novel immune therapies. Here, we analysed two different types of tissue microarrays of healthy lymphatic and various inflamed tissues, colorectal and lung cancers, as well as >1700 tumour samples from 86 different tumour entities for TIGIT and/or PD-1 by bright field and/or multiplex fluorescence immunohistochemistry. TIGIT was detected in CD8

Identifiants

pubmed: 30733837
doi: 10.1155/2019/5160565
pmc: PMC6348838
doi:

Substances chimiques

Receptors, Immunologic 0
TIGIT protein, human 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

5160565

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Auteurs

Niclas C Blessin (NC)

Institute of Pathology, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.

Ronald Simon (R)

Institute of Pathology, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.

Martina Kluth (M)

Institute of Pathology, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.

Kristine Fischer (K)

Dianova GmbH, Warburgstrasse 45, 20354 Hamburg, Germany.

Claudia Hube-Magg (C)

Institute of Pathology, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.

Wenchao Li (W)

Institute of Pathology, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.

Georgia Makrypidi-Fraune (G)

Institute of Pathology, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.

Björn Wellge (B)

Department of General, Visceral and Thoracic Surgery, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.

Tim Mandelkow (T)

Institute of Pathology, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.

Nicolaus F Debatin (NF)

Institute of Pathology, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.

Doris Höflmayer (D)

Institute of Pathology, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.

Maximilian Lennartz (M)

Institute of Pathology, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.

Guido Sauter (G)

Institute of Pathology, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.

Jakob R Izbicki (JR)

Department of General, Visceral and Thoracic Surgery, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.

Sarah Minner (S)

Institute of Pathology, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.

Franziska Büscheck (F)

Institute of Pathology, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.

Ria Uhlig (R)

Institute of Pathology, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.

David Dum (D)

Institute of Pathology, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.

Till Krech (T)

Institute of Pathology, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.

Andreas M Luebke (AM)

Institute of Pathology, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.

Corinna Wittmer (C)

Institute of Pathology, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.

Frank Jacobsen (F)

Institute of Pathology, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.

Eike-Christian Burandt (EC)

Institute of Pathology, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.

Stefan Steurer (S)

Institute of Pathology, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.

Waldemar Wilczak (W)

Institute of Pathology, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.

Andrea Hinsch (A)

Institute of Pathology, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.

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