Effect of Gestational Age on Maternofetal Vascular Function Following Single Maternal Engineered Nanoparticle Exposure.
Aerosols
Animals
Aorta, Thoracic
/ drug effects
Female
Fetus
/ blood supply
Gestational Age
Hemodynamics
/ drug effects
Inhalation Exposure
Maternal Exposure
Maternal-Fetal Exchange
/ drug effects
Metal Nanoparticles
/ toxicity
Pregnancy
Rats, Sprague-Dawley
Risk Assessment
Titanium
/ toxicity
Umbilical Arteries
/ drug effects
Uterine Artery
/ drug effects
Fetal aorta
Gestational exposure
Nanomaterials
Nanotoxicology
Umbilical vein
Uterine artery
Wire myography
Journal
Cardiovascular toxicology
ISSN: 1559-0259
Titre abrégé: Cardiovasc Toxicol
Pays: United States
ID NLM: 101135818
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
pubmed:
9
2
2019
medline:
6
5
2020
entrez:
9
2
2019
Statut:
ppublish
Résumé
Normal pregnancy outcome is accomplished, in part, by rapid and expansive physiological adaptations to the systemic circulation, the extent of which is specific to gestational day (GD) and anatomical location. Pregnancy-related hemodynamic changes in uterine placental blood flow stimulate compensatory vascular signaling and remodeling that begins early and continues throughout gestation. Exposure of the maternal environment to engineered nanomaterials (ENM) during pregnancy has been shown to impact health of the dam, fetus, and adult offspring; however, the consequences of specific temporal (gestational age) and spatial (vascular location) considerations are largely undetermined. We exposed pregnant Sprague-Dawley rats to nano-TiO
Identifiants
pubmed: 30734150
doi: 10.1007/s12012-019-09505-0
pii: 10.1007/s12012-019-09505-0
pmc: PMC6642065
mid: NIHMS1038501
doi:
Substances chimiques
Aerosols
0
titanium dioxide
15FIX9V2JP
Titanium
D1JT611TNE
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
321-333Subventions
Organisme : NIEHS NIH HHS
ID : R25 ES020721
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES005022
Pays : United States
Organisme : NIEHS NIH HHS
ID : R00 ES024783
Pays : United States
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