Toward in vivo determination of peripheral nervous system immune activity in amyotrophic lateral sclerosis.
Aged
Albumins
/ cerebrospinal fluid
Amyotrophic Lateral Sclerosis
/ diagnostic imaging
Female
Humans
Inflammation
/ diagnostic imaging
Male
Median Nerve
/ diagnostic imaging
Middle Aged
Mutation
Organ Size
Peripheral Nervous System
/ diagnostic imaging
ROC Curve
Serum Albumin
Superoxide Dismutase-1
/ genetics
Ulnar Nerve
/ diagnostic imaging
Ultrasonography
ALS
cerebrospinal fluid
peripheral nervous system
peripheral nervous system inflammation
peripheral neuropathy
ultrasound
Journal
Muscle & nerve
ISSN: 1097-4598
Titre abrégé: Muscle Nerve
Pays: United States
ID NLM: 7803146
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
accepted:
03
02
2019
pubmed:
9
2
2019
medline:
23
10
2019
entrez:
9
2
2019
Statut:
ppublish
Résumé
We sought to identify patients with amyotrophic lateral sclerosis (ALS) who displayed suspected peripheral nervous system (PNS) inflammation to compare them to those with suspected PNS degeneration. We measured sonographic median and ulnar nerve cross-sectional area (CSA) and cerebrospinal fluid albumin/serum albumin ratio (Q Fifty-seven percent of patients had suspected PNS degeneration, 21% had suspected PNS inflammation, and 21% displayed suspected "normal PNS state." Suspected PNS degeneration was related to classic ALS, shorter disease duration, and a smaller hypoechoic nerve area. Suspected PNS inflammation was associated with men, longer disease duration, and a larger hypoechoic nerve area and was the dominant finding in superoxide dismutase 1 mutation carriers. Our simple approach might aid in the in vivo differentiation of supposed ALS subtypes, those with suspected PNS degeneration vs. inflammation, for stratification in clinical trials. Muscle Nerve 59:567-567, 2019.
Substances chimiques
Albumins
0
Serum Albumin
0
Superoxide Dismutase-1
EC 1.15.1.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
567-576Informations de copyright
© 2019 Wiley Periodicals, Inc.