Long-term follow-up in patients treated with electrochemotherapy for non-melanoma skin cancer in the head and neck area.
Aged
Aged, 80 and over
Anesthesia, General
Bleomycin
/ therapeutic use
Carcinoma, Basal Cell
/ drug therapy
Carcinoma, Squamous Cell
/ drug therapy
Disease-Free Survival
Electrochemotherapy
/ methods
Female
Follow-Up Studies
Head and Neck Neoplasms
/ drug therapy
Humans
Injections, Intralesional
Male
Neoplasm Invasiveness
/ pathology
Neoplasm Recurrence, Local
/ mortality
Neoplasm Staging
Retrospective Studies
Risk Assessment
Sampling Studies
Skin Neoplasms
/ drug therapy
Survival Analysis
Time Factors
Wound Healing
/ physiology
Electrochemotherapy
basal cell carcinoma
non-melanoma skin cancer
squamous cell carcinoma
Journal
Acta oto-laryngologica
ISSN: 1651-2251
Titre abrégé: Acta Otolaryngol
Pays: England
ID NLM: 0370354
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
pubmed:
9
2
2019
medline:
14
8
2019
entrez:
9
2
2019
Statut:
ppublish
Résumé
Electrochemotherapy (ECT) is a cancer treatment modality where the intracellular accumulation of chemotherapeutic agents is enhanced by an applied electrical field. To evaluate the long-term efficacy, safety and functional outcome after ECT treatment in high-risk non-melanoma skin cancer (NMSC) with curative intent. Seven patients with SCC or BCC in the head and neck area were treated with ECT with intratumoral bleomycin administration. Five patients were cured by ECT as a mono-modality treatment after a median 10-year follow-up period. Two patients had recurrences and/or persisting tumors after treatment that required salvage surgery and radiotherapy. In two patients, the eye was spared with no visual impairment. In another patient, full facial nerve function was spared. ECT can be a curative as well as an organ and function-sparing mono modality treatment in high-risk NMSC. Today ECT is mostly used as a palliative treatment. Its curative potential should be further investigated. Randomized studies comparing ECT with standard treatment is needed. Hopefully, this small study can encourage such studies.
Sections du résumé
BACKGROUND
BACKGROUND
Electrochemotherapy (ECT) is a cancer treatment modality where the intracellular accumulation of chemotherapeutic agents is enhanced by an applied electrical field.
AIMS/OBJECTIVES
OBJECTIVE
To evaluate the long-term efficacy, safety and functional outcome after ECT treatment in high-risk non-melanoma skin cancer (NMSC) with curative intent.
MATERIALS AND METHODS
METHODS
Seven patients with SCC or BCC in the head and neck area were treated with ECT with intratumoral bleomycin administration.
RESULTS
RESULTS
Five patients were cured by ECT as a mono-modality treatment after a median 10-year follow-up period. Two patients had recurrences and/or persisting tumors after treatment that required salvage surgery and radiotherapy. In two patients, the eye was spared with no visual impairment. In another patient, full facial nerve function was spared.
CONCLUSIONS
CONCLUSIONS
ECT can be a curative as well as an organ and function-sparing mono modality treatment in high-risk NMSC.
SIGNIFICANCE
CONCLUSIONS
Today ECT is mostly used as a palliative treatment. Its curative potential should be further investigated. Randomized studies comparing ECT with standard treatment is needed. Hopefully, this small study can encourage such studies.
Identifiants
pubmed: 30734631
doi: 10.1080/00016489.2018.1543950
doi:
Substances chimiques
Bleomycin
11056-06-7
Types de publication
Evaluation Study
Journal Article
Langues
eng