Adamantinoma-Like Ewing Sarcoma of the Thyroid: A Case Report and Review of the Literature.
Adamantinoma-like Ewing sarcoma
Ewing sarcoma
Molecular diagnostics
Sarcoma
Thyroid
Journal
Head and neck pathology
ISSN: 1936-0568
Titre abrégé: Head Neck Pathol
Pays: United States
ID NLM: 101304010
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
06
12
2018
accepted:
03
02
2019
pubmed:
9
2
2019
medline:
18
4
2020
entrez:
9
2
2019
Statut:
ppublish
Résumé
Currently considered a variant of Ewing sarcoma, adamantinoma-like Ewing sarcoma is a rare malignancy that shows classic Ewing sarcoma-associated gene fusions but also epithelial differentiation. Here we present the 6th reported case of adamantinoma-like Ewing sarcoma involving the thyroid gland. Sections of the thyroid tumor from a 20-year old woman showed sheets, lobules and trabeculae of primitive, uniform, small round blue cells that diffusely expressed pankeratin, p40 and CD99. Fluorescent in situ hybridization revealed an EWSR1 gene rearrangement and an EWSR1-FLI1 fusion was detected by RT-PCR. Neck lymph nodes were not involved, and the patient was treated with a Ewing sarcoma chemotherapy protocol and radiation and is disease free 7 months after surgery. The unusual histology and immunohistochemical profile of adamantinoma-like Ewing sarcoma makes diagnosis and classification very challenging. We also present a literature review of adamantinoma-like Ewing sarcoma involving the thyroid.
Identifiants
pubmed: 30734898
doi: 10.1007/s12105-019-01021-5
pii: 10.1007/s12105-019-01021-5
pmc: PMC6854136
doi:
Substances chimiques
EWSR1-FLI1 fusion protein, human
0
Oncogene Proteins, Fusion
0
Types de publication
Case Reports
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
618-623Références
Bishop JA, Alaggio R, Zhang L, Seethala RR, Antonescu CR. Adamantinoma-like Ewing family tumors of the head and neck: a pitfall in the differential diagnosis of basaloid and myoepithelial carcinomas. Am J Surg Pathol. 2015;39:1267.
doi: 10.1097/PAS.0000000000000460
Weinreb I, Goldstein D, Perez-Ordoñez B. Primary extraskeletal Ewing family tumor with complex epithelial differentiation: a unique case arising in the lateral neck presenting with Horner syndrome. Am J Surg Pathol. 2008;32:1742–8.
doi: 10.1097/PAS.0b013e3181706252
Kikuchi Y, Kishimoto T, Ota S, et al. Adamantinoma-like Ewing family tumor of soft tissue associated with the vagus nerve: a case report and review of the literature. Am J Surg Pathol. 2013;37:772–9.
doi: 10.1097/PAS.0b013e31828e5168
Lezcano C, Clarke MR, Zhang L, Antonescu CR, Seethala RR. Adamantinoma-like Ewing sarcoma mimicking basal cell adenocarcinoma of the parotid gland: a case report and review of the literature. Head Neck Pathol. 2015;9:280–5.
doi: 10.1007/s12105-014-0558-0
Rooper LM, Jo VY, Antonescu CR, et al. Adamantinoma-like Ewing sarcoma of the salivary glands: a newly recognized mimicker of basaloid salivary carcinomas. Am J Surg Pathol. 2019;43:187–94.
doi: 10.1097/PAS.0000000000001171
Cruz J, Eloy C, Aragüés JM, Vinagre J, Sobrinho-Simões M. Small-cell (basaloid) thyroid carcinoma: a neoplasm with a solid cell nest histogenesis? Int J Surg Pathol. 2011;19:620–6.
doi: 10.1177/1066896911405320
Eloy C, Cameselle-Teijeiro J, Vieira J, et al. Carcinoma of the thyroid with Ewing/PNET family tumor elements: a tumor of unknown histogenesis. Int J Surg Pathol. 2014;22:579–81.
doi: 10.1177/1066896913486697
Eloy C, Oliveira M, Vieira J, et al. Carcinoma of the thyroid with Ewing family tumor elements and favorable prognosis: report of a second case. Int J Surg Pathol. 2014;22:260–5.
doi: 10.1177/1066896913486696
Ongkeko M, Zeck J, de Brito P. Molecular testing uncovers an Adamantinoma-like Ewing family of tumors in the thyroid: case report and review of literature. AJSP: Rev Rep. 2018;23:8–12.
Folpe AL, Goldblum JR, Rubin BP, et al. Morphologic and immunophenotypic diversity in Ewing family tumors: a study of 66 genetically confirmed cases. Am J Surg Pathol. 2005;29:1025–33.
pubmed: 16006796
Stevens TM, Qarmali M, Morlote D, et al. Malignant Ewing-like neoplasm with an EWSR1-KLF15 fusion: at the crossroads of a myoepithelial carcinoma and a Ewing-like sarcoma. A case report with treatment options. Int J Surg Pathol. 2018. https://doi.org/10.1177/1066896918755009
doi: 10.1177/1066896918755009
pubmed: 29390927
Verma A, Kane S, Vinarkar S, D’Cruz AK. Small cell medullary thyroid carcinoma: a diagnostic dilemma. Indian J Pathol Microbiol. 2017;60:562.
doi: 10.4103/IJPM.IJPM_187_17
Stevens TM, Morlote D, Swensen J, et al. Spindle epithelial tumor with thymus-like differentiation (SETTLE): a next-generation sequencing study. Head Neck Pathol. 2018. https://doi.org/10.1007/s12105-018-0927-1 .
doi: 10.1007/s12105-018-0927-1
pubmed: 29736783
pmcid: 6514029
Bishop JA, Andreasen S, Hang J-F, et al. HPV-related multiphenotypic sinonasal carcinoma. Am J Surg Pathol. 2017;41:1690–701.
doi: 10.1097/PAS.0000000000000944
Wong HH, Wang J. Merkel cell carcinoma. Arch Pathol Lab Med. 2010;134:1711–6.
pubmed: 21043828
Wenig BM. Squamous cell carcinoma of the upper aerodigestive tract: precursors and problematic variants. Mod Pathol. 2002;15:229.
doi: 10.1038/modpathol.3880520
Thompson LD. Olfactory neuroblastoma. Head Neck Pathol. 2009;3:252–9.
doi: 10.1007/s12105-009-0125-2
Haack H, Johnson LA, Fry CJ, et al. Diagnosis of NUT midline carcinoma using a NUT-specific monoclonal antibody. Am J Surg Pathol. 2009;33:984.
doi: 10.1097/PAS.0b013e318198d666
Lucas DR, Bentley G, Dan ME, et al. Ewing sarcoma vs lymphoblastic lymphoma: a comparative immunohistochemical study. Am J Clin Pathol. 2001;115:11–7.
doi: 10.1309/K1XJ-6CXR-BQQU-V255
Owosho AA, Estilo CL, Huryn JM, et al. Head and neck round cell sarcomas: a comparative clinicopathologic analysis of 2 molecular subsets: ewing and CIC-rearranged sarcomas. Head Neck Pathol. 2017;11:450–9.
doi: 10.1007/s12105-017-0808-z