Depression, lifestyle factors and cognitive function in people living with HIV and comparable HIV-negative controls.
HIV
HIV-associated neurocognitive disorders
cognitive disorder
cognitive function
depression
people living with HIV
Journal
HIV medicine
ISSN: 1468-1293
Titre abrégé: HIV Med
Pays: England
ID NLM: 100897392
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
accepted:
18
12
2018
pubmed:
9
2
2019
medline:
21
4
2020
entrez:
9
2
2019
Statut:
ppublish
Résumé
We investigated whether differences in cognitive performance between people living with HIV (PLWH) and comparable HIV-negative people were mediated or moderated by depressive symptoms and lifestyle factors. A cross-sectional study of 637 'older' PLWH aged ≥ 50 years, 340 'younger' PLWH aged < 50 years and 276 demographically matched HIV-negative controls aged ≥ 50 years enrolled in the Pharmacokinetic and Clinical Observations in People over Fifty (POPPY) study was performed. Cognitive function was assessed using a computerized battery (CogState). Scores were standardized into Z-scores [mean = 0; standard deviation (SD) = 1] and averaged to obtain a global Z-score. Depressive symptoms were evaluated via the Patient Health Questionnaire (PHQ-9). Differences between the three groups and the effects of depression, sociodemographic factors and lifestyle factors on cognitive performance were evaluated using median regression. All analyses accounted for age, gender, ethnicity and level of education. After adjustment for sociodemographic factors, older and younger PLWH had poorer overall cognitive scores than older HIV-negative controls (P < 0.001 and P = 0.006, respectively). Moderate or severe depressive symptoms were more prevalent in both older (27%; P < 0.001) and younger (21%; P < 0.001) PLWH compared with controls (8%). Depressive symptoms (P < 0.001) and use of hashish (P = 0.01) were associated with lower cognitive function; alcohol consumption (P = 0.02) was associated with better cognitive scores. After further adjustment for these factors, the difference between older PLWH and HIV-negative controls was no longer significant (P = 0.08), while that between younger PLWH and older HIV-negative controls remained significant (P = 0.01). Poorer cognitive performances in PLWH compared with HIV-negative individuals were, in part, mediated by the greater prevalence of depressive symptoms and recreational drug use reported by PLWH.
Identifiants
pubmed: 30734983
doi: 10.1111/hiv.12714
pmc: PMC6593457
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
274-285Subventions
Organisme : Medical Research Council
ID : MR/M004236/1
Pays : United Kingdom
Investigateurs
Daphne Babalis
(D)
Laura Burgess
(L)
Paddy Mallon
(P)
Memory Sachikonye
(M)
David Asboe
(D)
Lucy Garvey
(L)
Anton Pozniak
(A)
Amanda Clarke
(A)
Andrew Bexley
(A)
Celia Richardson
(C)
Sarah Kirk
(S)
Rebecca Gleig
(R)
Margherita Bracchi
(M)
Nicole Pagani
(N)
Maddalena Cerrone
(M)
Daniel Bradshaw
(D)
Francesca Ferretti
(F)
Chris Higgs
(C)
Elisha Seah
(E)
Stephen Fletcher
(S)
Michelle Anthonipillai
(M)
Ashley Moyes
(A)
Katie Deats
(K)
Irtiza Syed
(I)
Clive Matthews
(C)
Peter Fernando
(P)
Chido Chiwome
(C)
Shane Hardwick
(S)
Sifiso Mguni
(S)
Rebecca Clark
(R)
Rhiannon Nevin-Dolan
(R)
Sambasivarao Pelluri
(S)
Lucy Campbell
(L)
Selin Yurdakul
(S)
Sara Okumu
(S)
Louise Pollard
(L)
Beatriz Santana-Suarez
(B)
Alan Macken
(A)
Bijan Ghavani-Kia
(B)
Joanne Maher
(J)
Maria Byrne
(M)
Ailbhe Flaherty
(A)
Sumesh Babu
(S)
Damilola Otiko
(D)
Laura Phillips
(L)
Rosanna Laverick
(R)
Michelle Beynon
(M)
Anna-Lena Salz
(AL)
Abigail Severn
(A)
Lavender Tembo
(L)
Matthew Stott
(M)
Linda McDonald
(L)
Felix Dransfield
(F)
Andrew Whitehouse
(A)
Nnenna Ngwu
(N)
Nargis Hemat
(N)
Martin Jones
(M)
Anne Carroll
(A)
Sabine Kinloch
(S)
Mike Youle
(M)
Sara Madge
(S)
Informations de copyright
© 2019 The Authors. HIV Medicine published by John Wiley & Sons Ltd on behalf of British HIV Association.
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