Reactivation of a developmental
Animals
Bone Morphogenetic Protein 2
/ genetics
Cell Proliferation
/ genetics
DNA-Binding Proteins
/ genetics
Fractures, Bone
/ genetics
Gene Expression Regulation, Developmental
/ genetics
Homeodomain Proteins
/ genetics
Humans
Mice
Osteogenesis
/ genetics
Periosteum
/ growth & development
Signal Transduction
/ genetics
Smad1 Protein
/ genetics
Sp7 Transcription Factor
/ genetics
Transcription Factors
/ genetics
BMP
WNT
bone
cell biology
developmental biology
fracture
human
mouse
periosteum
skeletal
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
08 02 2019
08 02 2019
Historique:
received:
27
09
2018
accepted:
06
02
2019
pubmed:
9
2
2019
medline:
14
4
2020
entrez:
9
2
2019
Statut:
epublish
Résumé
Two decades after signals controlling bone length were discovered, the endogenous ligands determining bone width remain unknown. We show that postnatal establishment of normal bone width in mice, as mediated by bone-forming activity of the periosteum, requires BMP signaling at the innermost layer of the periosteal niche. This developmental signaling center becomes quiescent during adult life. Its reactivation however, is necessary for periosteal growth, enhanced bone strength, and accelerated fracture repair in response to bone-anabolic therapies used in clinical orthopedic settings. Although many BMPs are expressed in bone, periosteal BMP signaling and bone formation require only
Identifiants
pubmed: 30735122
doi: 10.7554/eLife.42386
pii: 42386
pmc: PMC6386520
doi:
pii:
Substances chimiques
BMP2 protein, human
0
Bmp2 protein, mouse
0
Bone Morphogenetic Protein 2
0
DNA-Binding Proteins
0
Grhl3 protein, mouse
0
Homeodomain Proteins
0
Prrx1 protein, mouse
0
Smad1 Protein
0
Smad1 protein, mouse
0
Sp7 Transcription Factor
0
Sp7 protein, mouse
0
Transcription Factors
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAMS NIH HHS
ID : P30 AR066261
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR055904
Pays : United States
Organisme : NIH HHS
ID : UM1 OD023221
Pays : United States
Informations de copyright
© 2019, Salazar et al.
Déclaration de conflit d'intérêts
VS, LC, CC, DZ, SP, KC, SO, MF, LG, JN, DC, KB, VR No competing interests declared, NG, AE Employee of Regeneron Pharmaceuticals. There are no other competing interests to declare.
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