Spatiotemporally Controlled Nuclear Translocation of Guests in Living Cells Using Caged Molecular Glues as Photoactivatable Tags.

Cell Line, Tumor Cell Nucleus / metabolism Cell Survival Endocytosis Endosomes / metabolism Guanidine / chemistry Humans Photons Quantum Dots / metabolism Ultraviolet Rays

Journal

Journal of visualized experiments : JoVE
ISSN: 1940-087X
Titre abrégé: J Vis Exp
Pays: United States
ID NLM: 101313252

Informations de publication

Date de publication:
17 01 2019
Historique:
entrez: 9 2 2019
pubmed: 9 2 2019
medline: 25 1 2020
Statut: epublish

Résumé

The cell nucleus is one of the most important organelles as a subcellular drug-delivery target, since modulation of gene replication and expression is effective for treating various diseases. Here, we demonstrate light-triggered nuclear translocation of guests using caged molecular glue (

Identifiants

DOI: 10.3791/58631 PMID: 30735192
pubmed: 30735192
doi: 10.3791/58631
doi:

Substances chimiques

Guanidine JU58VJ6Y3B

Types de publication

Journal Article Research Support, Non-U.S. Gov't Video-Audio Media

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Rina Mogaki (R)

Department of Chemistry and Biotechnology, School of Engineering, University of Tokyo.

Kou Okuro (K)

Department of Chemistry and Biotechnology, School of Engineering, University of Tokyo; okuro@macro.t.u-tokyo.ac.jp.

Akio Arisaka (A)

Department of Chemistry and Biotechnology, School of Engineering, University of Tokyo.

Takuzo Aida (T)

Department of Chemistry and Biotechnology, School of Engineering, University of Tokyo; Riken Center for Emergent Matter Science; aida@macro.t.u-tokyo.ac.jp.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Spatiotemporally Controlled Nuclear...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Noyau de la cellule › Spatiotemporally Controlled Nuclear...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Spatiotemporally Controlled Nuclear...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Endocytose › Spatiotemporally Controlled Nuclear...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Vésicules de transport › Endosomes › Spatiotemporally Controlled Nuclear...
questionsmedicales.fr › Composés chimiques organiques › Amidines › Guanidines › Guanidine › Spatiotemporally Controlled Nuclear...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Spatiotemporally Controlled Nuclear...
questionsmedicales.fr › Phénomènes physiques › Rayonnement › Rayonnement non ionisant › Lumière › Photons › Spatiotemporally Controlled Nuclear...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Boîtes quantiques › Spatiotemporally Controlled Nuclear...
questionsmedicales.fr › Environnement et santé publique › Environnement › Concepts météorologiques › Atmosphère › Temps (météorologie) › Lumière du soleil › Rayons ultraviolets › Spatiotemporally Controlled Nuclear...