The Impact of Past and Current Alcohol Consumption Patterns on Progression of Carotid Intima-Media Thickness Among Women and Men Living with HIV Infection.
Alcohol
Atherosclerosis
Cardiovascular Disease
Carotid Intima-Media Thickness
HIV
Journal
Alcoholism, clinical and experimental research
ISSN: 1530-0277
Titre abrégé: Alcohol Clin Exp Res
Pays: England
ID NLM: 7707242
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
30
08
2018
accepted:
26
01
2019
pubmed:
9
2
2019
medline:
7
7
2020
entrez:
9
2
2019
Statut:
ppublish
Résumé
The relationship between alcohol consumption and atherosclerosis has not been sufficiently examined among people living with HIV (PLWH). We analyzed data from PLWH in the Women's Interagency HIV Study (WIHS; n = 1,164) and the Multicenter AIDS Cohort Study (MACS; n = 387) with no history of cardiovascular disease (CVD). Repeated measures of intima-media thickness of the right common carotid artery (CCA-IMT) were assessed using B-mode ultrasound from 2004 to 2013. Current alcohol consumption was collected at time of CCA-IMT measurement and was categorized according to gender-specific weekly limits. Group-based trajectory models categorized participants into past 10-year consumption patterns (1994 to 2004). Multivariate generalized estimating equations were conducted to assess the association of past and current alcohol use patterns on change in CCA-IMT by cohort, controlling for age, race, cigarette and illicit drug use, probable depression, HIV RNA viral load, antiretroviral therapy exposure, and hepatitis C coinfection. Among the WIHS, past heavy alcohol consumption was associated with increased CCA-IMT level over time (β = 8.08, CI 0.35, 15.8, p = 0.04), compared to abstinence. Among the MACS, compared to abstinence, all past consumption patterns were associated with increased CCA-IMT over time (past low: β = 15.3, 95% CI 6.46, 24.2, p < 0.001; past moderate: β = 14.3, CI 1.36, 27.2, p = 0.03; past heavy: β = 21.8, CI 4.63, 38.9, p = 0.01). Current heavy consumption was associated with decreased CCA-IMT among the WIHS (β = -11.4, 95% CI -20.2, -2.63, p = 0.01) and MACS (β = -15.4, 95% CI -30.7, -0.13, p = 0.04). No statistically significant time by consumption pattern effects were found. In both cohorts, 10-year heavy consumption was associated with statistically significant increases in carotid artery thickness, compared to abstinence. Long-term patterns of drinking at any level above abstinence were particularly significant for increases in IMT among men, with heavy consumption presenting with the greatest increase. Our results suggest a potentially different window of risk among past and current heavy drinkers. Further studies are needed to determine whether alcohol consumption level is associated with intermediate measures of atherosclerosis. Alcohol screening and interventions to reduce heavy consumption may benefit PLWH who are at risk of CVD.
Sections du résumé
BACKGROUND
The relationship between alcohol consumption and atherosclerosis has not been sufficiently examined among people living with HIV (PLWH).
METHODS
We analyzed data from PLWH in the Women's Interagency HIV Study (WIHS; n = 1,164) and the Multicenter AIDS Cohort Study (MACS; n = 387) with no history of cardiovascular disease (CVD). Repeated measures of intima-media thickness of the right common carotid artery (CCA-IMT) were assessed using B-mode ultrasound from 2004 to 2013. Current alcohol consumption was collected at time of CCA-IMT measurement and was categorized according to gender-specific weekly limits. Group-based trajectory models categorized participants into past 10-year consumption patterns (1994 to 2004). Multivariate generalized estimating equations were conducted to assess the association of past and current alcohol use patterns on change in CCA-IMT by cohort, controlling for age, race, cigarette and illicit drug use, probable depression, HIV RNA viral load, antiretroviral therapy exposure, and hepatitis C coinfection.
RESULTS
Among the WIHS, past heavy alcohol consumption was associated with increased CCA-IMT level over time (β = 8.08, CI 0.35, 15.8, p = 0.04), compared to abstinence. Among the MACS, compared to abstinence, all past consumption patterns were associated with increased CCA-IMT over time (past low: β = 15.3, 95% CI 6.46, 24.2, p < 0.001; past moderate: β = 14.3, CI 1.36, 27.2, p = 0.03; past heavy: β = 21.8, CI 4.63, 38.9, p = 0.01). Current heavy consumption was associated with decreased CCA-IMT among the WIHS (β = -11.4, 95% CI -20.2, -2.63, p = 0.01) and MACS (β = -15.4, 95% CI -30.7, -0.13, p = 0.04). No statistically significant time by consumption pattern effects were found.
CONCLUSIONS
In both cohorts, 10-year heavy consumption was associated with statistically significant increases in carotid artery thickness, compared to abstinence. Long-term patterns of drinking at any level above abstinence were particularly significant for increases in IMT among men, with heavy consumption presenting with the greatest increase. Our results suggest a potentially different window of risk among past and current heavy drinkers. Further studies are needed to determine whether alcohol consumption level is associated with intermediate measures of atherosclerosis. Alcohol screening and interventions to reduce heavy consumption may benefit PLWH who are at risk of CVD.
Identifiants
pubmed: 30735256
doi: 10.1111/acer.13974
pmc: PMC6443465
mid: NIHMS1011263
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
695-703Subventions
Organisme : NIAID NIH HHS
ID : U01 AI035042
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL095140
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI051519
Pays : United States
Organisme : NIMH NIH HHS
ID : P30 MH058107
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL095129
Pays : United States
Organisme : NCI NIH HHS
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002378
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI035039
Pays : United States
Organisme : NIDA NIH HHS
Pays : United States
Organisme : NIDCD NIH HHS
Pays : United States
Organisme : NIDCR NIH HHS
Pays : United States
Organisme : NHLBI NIH HHS
ID : R21 HL120394
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL126543
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL083760
Pays : United States
Organisme : NCATS NIH HHS
ID : TL1 TR002244
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL146201
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI124414
Pays : United States
Organisme : NCATS NIH HHS
ID : KL2 TR001429
Pays : United States
Informations de copyright
© 2019 by the Research Society on Alcoholism.
Références
Clin Chem. 2016 Sep;62(9):1202-10
pubmed: 27440513
AIDS. 2009 Jun 1;23(9):1059-67
pubmed: 19390417
Arterioscler Thromb Vasc Biol. 2012 Sep;32(9):2045-51
pubmed: 22895665
Epidemiology. 1998 Mar;9(2):117-25
pubmed: 9504278
Clin Infect Dis. 2015 Aug 15;61(4):640-50
pubmed: 25904369
PLoS One. 2016 Jan 26;11(1):e0147822
pubmed: 26811937
PLoS One. 2015 Nov 13;10(11):e0142706
pubmed: 26566285
J Nerv Ment Dis. 2000 Oct;188(10):662-70
pubmed: 11048815
Nutr Metab Cardiovasc Dis. 2013 Jun;23(6):487-504
pubmed: 23642930
J Am Heart Assoc. 2012 Apr;1(2):
pubmed: 23130122
Am J Epidemiol. 1995 Aug 1;142(3):323-30
pubmed: 7631636
Cardiovasc Ultrasound. 2015 Dec 15;13:46
pubmed: 26666335
Drug Alcohol Depend. 2017 Dec 1;181:235-241
pubmed: 29121596
Curr Atheroscler Rep. 2014 Sep;16(9):435
pubmed: 25037581
BMJ. 2017 Mar 22;356:j909
pubmed: 28331015
Stroke. 2005 Aug;36(8):1746-52
pubmed: 16002763
Curr Atheroscler Rep. 2012 Apr;14(2):108-14
pubmed: 22350634
Psychol Methods. 2001 Mar;6(1):18-34
pubmed: 11285809
Am J Cardiol. 2005 Apr 15;95(8):1006-10
pubmed: 15820179
Clin Diagn Lab Immunol. 2005 Sep;12(9):1013-9
pubmed: 16148165
J Am Heart Assoc. 2016 Jun 27;5(6):
pubmed: 27353609
BMC Public Health. 2006 May 03;6:118
pubmed: 16670030
Annu Rev Immunol. 2012;30:149-73
pubmed: 22224779
Mayo Clin Proc. 2009 Mar;84(3):229-33
pubmed: 19252109
BMC Public Health. 2009 Sep 23;9:358
pubmed: 19775442
AIDS. 2009 Sep 10;23(14):1841-9
pubmed: 19455012
Ann Intern Med. 2001 Dec 4;135(11):939-53
pubmed: 11730394
Eur J Prev Cardiol. 2013 Oct;20(5):720-8
pubmed: 22556374
Nat Rev Gastroenterol Hepatol. 2016 Jul;13(7):412-25
pubmed: 27273168
J Cardiovasc Pharmacol Ther. 2014 Mar;19(2):170-8
pubmed: 24177335
N Engl J Med. 2006 Nov 30;355(22):2283-96
pubmed: 17135583
Eur J Clin Nutr. 2010 Oct;64(10):1199-206
pubmed: 20664623
Arch Intern Med. 1999 Aug 9-23;159(15):1681-9
pubmed: 10448769
J Infect Dis. 2010 Jun 15;201(12):1788-95
pubmed: 20446848
Am J Epidemiol. 1987 Aug;126(2):310-8
pubmed: 3300281
AIDS. 2008 Aug 20;22(13):1615-24
pubmed: 18670221
Atherosclerosis. 2001 Jan;154(1):185-93
pubmed: 11137099
PLoS One. 2013;8(1):e53028
pubmed: 23326376
Am J Drug Alcohol Abuse. 2018;44(1):85-94
pubmed: 28621562
Arterioscler Thromb Vasc Biol. 2014 Feb;34(2):244-50
pubmed: 24265418
Addiction. 2003 Dec;98 Suppl 2:1-12
pubmed: 14984237
Arch Intern Med. 2011 Apr 25;171(8):737-43
pubmed: 21518940
Eur Heart J. 2015 Apr 14;36(15):939-45
pubmed: 25602025
J Acquir Immune Defic Syndr. 2010 Feb;53(2):247-53
pubmed: 20009766
Circulation. 1999 Aug 24;100(8):838-42
pubmed: 10458720
Nat Rev Cardiol. 2015 Oct;12(10):576-87
pubmed: 26099843
Nurs Res. 2014 Sep-Oct;63(5):375-85
pubmed: 25171563