Dysfunction of attention switching networks in amyotrophic lateral sclerosis.
Amyotrophic lateral sclerosis
Cognition
EEG
Mismatch negativity
Network
Source localisation
Journal
NeuroImage. Clinical
ISSN: 2213-1582
Titre abrégé: Neuroimage Clin
Pays: Netherlands
ID NLM: 101597070
Informations de publication
Date de publication:
2019
2019
Historique:
received:
25
10
2018
revised:
28
01
2019
accepted:
31
01
2019
pubmed:
9
2
2019
medline:
21
12
2019
entrez:
9
2
2019
Statut:
ppublish
Résumé
To localise and characterise changes in cognitive networks in Amyotrophic Lateral Sclerosis (ALS) using source analysis of mismatch negativity (MMN) waveforms. The MMN waveform has an increased average delay in ALS. MMN has been attributed to change detection and involuntary attention switching. This therefore indicates pathological impairment of the neural network components which generate these functions. Source localisation can mitigate the poor spatial resolution of sensor-level EEG analysis by associating the sensor-level signals to the contributing brain sources. The functional activity in each generating source can therefore be individually measured and investigated as a quantitative biomarker of impairment in ALS or its sub-phenotypes. MMN responses from 128-channel electroencephalography (EEG) recordings in 58 ALS patients and 39 healthy controls were localised to source by three separate localisation methods, including beamforming, dipole fitting and exact low resolution brain electromagnetic tomography. Compared with controls, ALS patients showed significant increase in power of the left posterior parietal, central and dorsolateral prefrontal cortices (false discovery rate = 0.1). This change correlated with impaired cognitive flexibility (rho = 0.45, 0.45, 0.47, p = .042, .055, .031 respectively). ALS patients also exhibited a decrease in the power of dipoles representing activity in the inferior frontal (left: p = 5.16 × 10 Source localization of evoked potentials can reliably discriminate patterns of functional network impairment in ALS and ALS subgroups during involuntary attention switching. The discriminative ability of the detected cognitive changes in specific brain regions are comparable to those of functional magnetic resonance imaging (fMRI). Source analysis of high-density EEG patterns has excellent potential to provide non-invasive, data-driven quantitative biomarkers of network disruption that could be harnessed as novel neurophysiology-based outcome measures in clinical trials.
Identifiants
pubmed: 30735860
pii: S2213-1582(19)30057-9
doi: 10.1016/j.nicl.2019.101707
pmc: PMC6365983
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
101707Subventions
Organisme : Motor Neurone Disease Association
ID : HARDIMAN/OCT15/879-792
Pays : United Kingdom
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.
Références
Neuroimage. 2011 Jan 1;54(1):313-27
pubmed: 20656036
Neurology. 2018 Oct 9;91(15):e1370-e1380
pubmed: 30209236
Clin Neurophysiol. 2012 Mar;123(3):424-58
pubmed: 22169062
Neuroimage. 2000 Jul;12(1):14-9
pubmed: 10875898
Front Hum Neurosci. 2014 Mar 24;8:156
pubmed: 24715858
Front Behav Neurosci. 2014 May 30;8:171
pubmed: 24910597
Brain Imaging Behav. 2018 Dec;12(6):1696-1707
pubmed: 29423814
J Neurol. 2005 Jul;252(7):772-81
pubmed: 15742104
Psychophysiology. 2010 Jan 1;47(1):66-122
pubmed: 19686538
Schizophr Res. 2005 Jul 1;76(1):25-41
pubmed: 15927796
Ear Hear. 1995 Feb;16(1):6-18
pubmed: 7774770
Eur J Neurosci. 2009 Oct;30(8):1620-4
pubmed: 19811535
J Cogn Neurosci. 1996 Nov;8(6):527-39
pubmed: 23961983
Amyotroph Lateral Scler Frontotemporal Degener. 2017 Feb;18(1-2):99-106
pubmed: 27894201
Comput Intell Neurosci. 2009;:656092
pubmed: 19639045
Neuropsychologia. 2015 Aug;75:242-51
pubmed: 26100559
Conf Proc IEEE Eng Med Biol Soc. 2017 Jul;2017:3949-3952
pubmed: 29060761
Clin Neurophysiol. 2007 Mar;118(3):597-605
pubmed: 17239656
Ear Hear. 1995 Feb;16(1):38-51
pubmed: 7774768
J Comput Neurosci. 1999 Mar-Apr;6(2):99-120
pubmed: 10333158
Neuropsychologia. 2014 Nov;64:92-8
pubmed: 25245940
Neuroimage Clin. 2018 Aug 04;20:564-571
pubmed: 30186760
Neuroimage. 2002 Sep;17(1):231-9
pubmed: 12482080
J Neurosci. 2007 Feb 28;27(9):2349-56
pubmed: 17329432
Neurology. 2018 Apr 17;90(16):e1418-e1424
pubmed: 29661904
Eur J Neurosci. 2001 Sep;14(5):877-83
pubmed: 11576192
Front Psychiatry. 2013 Dec 18;4:171
pubmed: 24391602
Dev Cogn Neurosci. 2017 Dec;28:65-75
pubmed: 29182947
IEEE Trans Biomed Eng. 1997 Sep;44(9):867-80
pubmed: 9282479
J Am Stat Assoc. 2009 Sep 1;104(487):1015-1028
pubmed: 20333278
J Neurol Neurosurg Psychiatry. 2012 Apr;83(4):365-7
pubmed: 22399794
Comput Intell Neurosci. 2011;2011:156869
pubmed: 21253357
Neuroimage. 2002 Jan;15(1):273-89
pubmed: 11771995
Neurol Clin Neurophysiol. 2004 Nov 30;2004:20
pubmed: 16012601
Neuroreport. 2001 Aug 8;12(11):2583-7
pubmed: 11496153
Electroencephalogr Clin Neurophysiol. 1994 Nov;91(5):353-62
pubmed: 7525232
J Neurol Neurosurg Psychiatry. 2015 Apr;86(4):468-70
pubmed: 25053771
Psychophysiology. 1990 Nov;27(6):627-40
pubmed: 2100348
Neuroimage. 2004;23 Suppl 1:S289-99
pubmed: 15501098
Eur J Neurosci. 2003 Oct;18(8):2408-12
pubmed: 14622204
Nat Neurosci. 2000 Mar;3(3):284-91
pubmed: 10700262
Brain Topogr. 1991 Winter;4(2):143-50
pubmed: 1793688
Brain. 2018 Jun 1;141(6):1770-1781
pubmed: 29701820
BMC Psychiatry. 2006 Feb 08;6:7
pubmed: 16466573
Neurobiol Aging. 2013 Feb;34(2):419-27
pubmed: 22608240
Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6809-14
pubmed: 15096618
Amyotroph Lateral Scler Frontotemporal Degener. 2017 Feb;18(1-2):68-73
pubmed: 27894191
Curr Alzheimer Res. 2004 Feb;1(1):63-9
pubmed: 15975087
Acta Psychol (Amst). 1978 Jul;42(4):313-29
pubmed: 685709
Hum Brain Mapp. 2018 Jan;39(1):104-119
pubmed: 28990264
Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):676-82
pubmed: 11209064
Lancet Neurol. 2012 Mar;11(3):232-40
pubmed: 22305801
Clin Neurophysiol. 2014 Sep;125(9):1774-82
pubmed: 24560133
Biol Psychol. 1979 Mar;8(2):81-136
pubmed: 465623
Brain. 2006 Sep;129(Pt 9):2436-46
pubmed: 16835248
Neuroimage. 2002 Jan;15(1):167-74
pubmed: 11771985
J Cogn Neurosci. 2004 Mar;16(2):289-300
pubmed: 15068598
Brain. 2001 Oct;124(Pt 10):2074-86
pubmed: 11571223
Front Neurol. 2017 Aug 15;8:395
pubmed: 28861032
J Comput Assist Tomogr. 1998 Mar-Apr;22(2):324-33
pubmed: 9530404
Nat Neurosci. 2003 Apr;6(4):391-8
pubmed: 12652303
Front Hum Neurosci. 2013 Jun 10;7:251
pubmed: 23772210
PLoS One. 2016 Dec 1;11(12):e0167331
pubmed: 27907080
Neuroimage. 2007 Aug 15;37(2):561-71
pubmed: 17596966
Cereb Cortex. 2019 Jan 1;29(1):27-41
pubmed: 29136131
PLoS One. 2014 Mar 11;9(3):e91441
pubmed: 24618596
Caspian J Intern Med. 2013 Spring;4(2):627-35
pubmed: 24009950
Lancet. 2011 Mar 12;377(9769):942-55
pubmed: 21296405
Brain Struct Funct. 2010 Jun;214(5-6):655-67
pubmed: 20512370
Clin Neurophysiol. 2007 Dec;118(12):2544-90
pubmed: 17931964
Lancet Neurol. 2007 Nov;6(11):994-1003
pubmed: 17945153
Clin Neurophysiol. 2002 May;113(5):702-12
pubmed: 11976050
Brain Topogr. 2002 Fall;15(1):13-27
pubmed: 12371672
Eur Psychiatry. 2016 Apr;34:9-16
pubmed: 26928341
Amyotroph Lateral Scler Frontotemporal Degener. 2015;17(1-2):85-92
pubmed: 26458122
Hum Brain Mapp. 2013 Aug;34(8):1896-909
pubmed: 22431268
Neuron. 2013 Dec 4;80(5):1112-28
pubmed: 24314724
Brain Topogr. 2014 Jul;27(4):451-66
pubmed: 24838819
J Comp Neurol. 2000 Jan 3;416(1):79-92
pubmed: 10578103
Philos Trans A Math Phys Eng Sci. 2011 Oct 13;369(1952):3768-84
pubmed: 21893527
Neuroreport. 2001 Mar 5;12(3):573-7
pubmed: 11234766
Front Hum Neurosci. 2016 Jun 28;10:311
pubmed: 27445751
Brain Res. 1996 Dec 2;742(1-2):239-52
pubmed: 9117400
Psychophysiology. 1992 Sep;29(5):523-34
pubmed: 1410181
Biol Psychol. 2016 Apr;116:41-6
pubmed: 26342995