In utero metal exposures measured in deciduous teeth and birth outcomes in a racially-diverse urban cohort.
Birth outcome
Birth weight
Gestational age
Metals
Teeth
Journal
Environmental research
ISSN: 1096-0953
Titre abrégé: Environ Res
Pays: Netherlands
ID NLM: 0147621
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
08
10
2018
revised:
29
01
2019
accepted:
30
01
2019
pubmed:
9
2
2019
medline:
18
12
2019
entrez:
9
2
2019
Statut:
ppublish
Résumé
A growing number of studies have examined associations of metal exposures with birth outcomes, however, results from these studies have been inconsistent, and hampered by methodological limitations. We measured direct fetal exposure to three metals (lead, manganese and zinc) during the second and third trimester and examined its association with birth weight and gestational age at delivery. Participants in the Wayne County Health, Environment, Allergy and Asthma Longitudinal Study (WHEALS), a population-based birth cohort established between September 2003 and December 2007, were invited to donate teeth to the study. Lead, manganese and zinc during the second and third trimesters were measured via high-resolution microspatial mapping of dentin growth rings, a validated biomarker for prenatal metal exposure. Gestational age at delivery and infant birth weight were obtained from the delivery medical record. A total of 145 children had tooth metal measurements and birth outcome data. Mean birth weight was 3431 ± 472 g and mean gestational age at delivery was 39.0 ± 1.3 weeks. Overall, there was a positive association between second (β = 0.21, 95% CI: 0.05, 0.37, P = 0.01) and third trimester (β = 0.21, 95% CI: 0.05, 0.37, P = 0.01) tooth manganese and birth weight Z-score; this remained statistically significant after covariate adjustment. There was also a negative association between second trimester tooth lead level and birth weight Z-score (β = -0.20, 95% CI: -0.38, -0.02, P = 0.02), however, this was attenuated after adjusting for covariates. Mixture analysis revealed similar findings. There was evidence for a sex-specific effect of manganese with birth weight Z-score, with the association stronger in female compared to male infants. Overall, we found evidence suggesting that higher in utero manganese is associated with larger birth weight Z-scores and that these associations may vary by infant sex.
Identifiants
pubmed: 30735952
pii: S0013-9351(19)30069-6
doi: 10.1016/j.envres.2019.01.054
pmc: PMC6402585
mid: NIHMS1521347
pii:
doi:
Substances chimiques
Environmental Pollutants
0
Metals
0
Lead
2P299V784P
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
444-451Subventions
Organisme : NIEHS NIH HHS
ID : R01 ES026033
Pays : United States
Organisme : NIOSH CDC HHS
ID : T42 OH008455
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL113010
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES023515
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES020957
Pays : United States
Organisme : NICHD NIH HHS
ID : K99 HD087523
Pays : United States
Organisme : NIEHS NIH HHS
ID : DP2 ES025453
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI110450
Pays : United States
Organisme : NIEHS NIH HHS
ID : R21 ES022321
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI089473
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI050681
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES017885
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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