Differential expression of estrogen receptor-α on follicular dendritic cells from patients with grade 1-2 and grade 3 follicular lymphoma.
CD23
estrogen receptor alpha
follicular dendritic cell
follicular lymphoma
Journal
Hematological oncology
ISSN: 1099-1069
Titre abrégé: Hematol Oncol
Pays: England
ID NLM: 8307268
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
08
01
2019
revised:
27
01
2019
accepted:
05
02
2019
pubmed:
9
2
2019
medline:
8
5
2019
entrez:
9
2
2019
Statut:
ppublish
Résumé
Hormone therapy has been used for patients with estrogen receptor alpha (ERα)-positive breast cancers. Recently, some studies reported the expression of ERα on neoplastic cells from B-cell lymphomas. However, there has been only one report of ERα expression on the follicular dendritic cells (FDCs) that structurally and functionally support the microenvironment of follicular lymphomas (FLs). The objective of this study was to investigate the frequency of ERα expression on FDCs in nonneoplastic reactive lymphoid tissues and to compare the frequency of ERα expression on FDCs in the axillary lymph nodes between patients with and without antiestrogen therapy and among patients with grades 1-3 of FL. Reverse transcription-polymerase chain reaction was performed to detect ERα mRNA in FL. In nonneoplastic germinal centers (GCs) from patients with tonsillitis or reactive lymphadenitis, ERα was expressed in the light zone. ERα-positive cells strongly correlated with the width of GCs (r
Identifiants
pubmed: 30736096
doi: 10.1002/hon.2577
pmc: PMC6593816
doi:
Substances chimiques
ESR1 protein, human
0
Estrogen Receptor alpha
0
Neoplasm Proteins
0
Types de publication
Clinical Trial
Comparative Study
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
151-159Subventions
Organisme : Japan Society for the Promotion of Science
ID : JP17K08736
Informations de copyright
© 2019 The Authors Hematological Oncology Published by John Wiley & Sons Ltd.
Références
Br J Haematol. 2016 Oct;175(1):102-14
pubmed: 27341313
Hematol Oncol. 2019 Apr;37(2):151-159
pubmed: 30736096
Leuk Lymphoma. 2017 Mar;58(3):528-539
pubmed: 27557932
Leuk Lymphoma. 2016 Jul;57(7):1687-96
pubmed: 26700650
Semin Cancer Biol. 2015 Oct;34:3-13
pubmed: 25794825
Transl Res. 2015 Sep;166(3):281-91
pubmed: 25953661
PLoS One. 2016 Feb 22;11(2):e0147358
pubmed: 26900851
N Engl J Med. 2015 Jul 16;373(3):209-19
pubmed: 26030518
Mol Cell Endocrinol. 2015 Dec 15;418 Pt 3:264-72
pubmed: 25597633
Nat Methods. 2012 Jul;9(7):671-5
pubmed: 22930834
Am J Pathol. 1999 Sep;155(3):805-14
pubmed: 10487838
Histopathology. 2011 Mar;58(4):586-92
pubmed: 21401698
Am J Pathol. 2003 Oct;163(4):1313-20
pubmed: 14507640
Leukemia. 2001 Jan;15(1):148-56
pubmed: 11243383
Br J Haematol. 2012 Jul;158(1):79-90
pubmed: 22509798
Hematol Oncol. 2011 Sep;29(3):147-50
pubmed: 20824654
Pathol Int. 2011 Dec;61(12):737-41
pubmed: 22126381