Multimodal Intervention to Improve Functional Status in Hypertensive Older Adults: A Pilot Randomized Controlled Trial.
aging
angiotensin-converting enzyme inhibitors
antihypertensive medication
exercise
functional status
hypertension
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
06 Feb 2019
06 Feb 2019
Historique:
received:
26
12
2018
revised:
30
01
2019
accepted:
31
01
2019
entrez:
10
2
2019
pubmed:
10
2
2019
medline:
10
2
2019
Statut:
epublish
Résumé
This pilot randomized controlled trial (RCT) was designed to provide the preliminary data necessary to conduct a full-scale trial to compare the efficacy of differing first-line antihypertensive medications in improving functional status in older adults, when combined with exercise. The primary objectives were to assess study feasibility, safety, and protocol integrity. Dependent outcomes included gait speed, exercise capacity, body composition, and systemic cardiometabolic biomarkers. Thirty-one physically inactive older adults (70.6 ± 6.1 years) with hypertension and functional limitations were randomly assigned to 1) Perindopril (8 mg/day
Identifiants
pubmed: 30736317
pii: jcm8020196
doi: 10.3390/jcm8020196
pmc: PMC6406861
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIA NIH HHS
ID : R01AG056769
Pays : United States
Organisme : NIA NIH HHS
ID : P30AG028740
Pays : United States
Organisme : National Center for Medical Rehabilitation Research
ID : P2CHD086851, T32HD071866
Organisme : NIA NIH HHS
ID : P30 AG028740
Pays : United States
Organisme : American Heart Association
ID : 13SDG17080033
Organisme : NIA NIH HHS
ID : R01 AG056769
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD071866
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest
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