Studies on Cell Compatibility, Antibacterial Behavior, and Zeta Potential of Ag-Containing Polydopamine-Coated Bioactive Glass-Ceramic.

antibacterial bioactive glass-ceramic biocompatibility coatings polydopamine silver

Journal

Materials (Basel, Switzerland)
ISSN: 1996-1944
Titre abrégé: Materials (Basel)
Pays: Switzerland
ID NLM: 101555929

Informations de publication

Date de publication:
06 Feb 2019
Historique:
received: 23 12 2018
revised: 18 01 2019
accepted: 29 01 2019
entrez: 10 2 2019
pubmed: 10 2 2019
medline: 10 2 2019
Statut: epublish

Résumé

Dopamine is a small molecule that mimics the adhesive component (L-DOPA) of marine mussels with a catecholamine structure. Dopamine can spontaneously polymerize to form polydopamine (PDA) in a mild basic environment. PDA binds, in principle, to all types of surfaces and offers a platform for post-modification of surfaces. In this work, a novel Ag-containing polydopamine coating has been developed for the functionalization of bioactive glass-ceramics. In order to study the interactions between the surface of uncoated and coated samples and the environment, we have measured the surface zeta potential. Results confirmed that PDA can interact with the substrate through different chemical groups. A strongly negative surface zeta potential was measured, which is desirable for biocompatibility. The dual function of the material, namely the capability to exhibit bioactive behavior while being antibacterial and not harmful to mammalian cells, was assessed. The biocompatibility of the samples with MG-63 (osteoblast-like) cells was determined, as well as the antibacterial behavior against Gram-positive

Identifiants

pubmed: 30736344
pii: ma12030500
doi: 10.3390/ma12030500
pmc: PMC6384827
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Horizon 2020 Framework Programme
ID : 642557

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

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Auteurs

Rocío Tejido-Rastrilla (R)

Institute of Biomaterials, University of Erlangen-Nuremberg, 91058 Erlangen, Germany. rocio.tejido@fau.de.
Colorobbia Consulting s.r.l., 50053 Sovigliana Vinci, Florence, Italy. rocio.tejido@fau.de.

Sara Ferraris (S)

Department of Applied Science and Technology, Politecnico di Torino, 10129 Torino, Italy. sara.ferraris@polito.it.

Wolfgang H Goldmann (WH)

Centre for Medical Physics and Technology, University of Erlangen-Nuremberg, 91052 Erlangen, Germany. wgoldmann@biomed.uni-erlangen.de.

Alina Grünewald (A)

Institute of Biomaterials, University of Erlangen-Nuremberg, 91058 Erlangen, Germany. alina.gruenewald@fau.de.

Rainer Detsch (R)

Institute of Biomaterials, University of Erlangen-Nuremberg, 91058 Erlangen, Germany. rainer.detsch@fau.de.

Giovanni Baldi (G)

Colorobbia Consulting s.r.l., 50053 Sovigliana Vinci, Florence, Italy. baldig@colorobbia.it.

Silvia Spriano (S)

Department of Applied Science and Technology, Politecnico di Torino, 10129 Torino, Italy. silvia.spriano@polito.it.

Aldo R Boccaccini (AR)

Institute of Biomaterials, University of Erlangen-Nuremberg, 91058 Erlangen, Germany. aldo.boccaccini@ww.uni-erlangen.de.

Classifications MeSH