Retroelement-Linked Transcription Factor Binding Patterns Point to Quickly Developing Molecular Pathways in Human Evolution.

ChIP-seq Human genome evolution gene ontology molecular pathways omics approach in genetics retrotransposons transcription factor

Journal

Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052

Informations de publication

Date de publication:
06 02 2019
Historique:
received: 20 12 2018
revised: 29 01 2019
accepted: 30 01 2019
entrez: 10 2 2019
pubmed: 10 2 2019
medline: 10 2 2019
Statut: epublish

Résumé

Retroelements (REs) are transposable elements occupying ~40% of the human genome that can regulate genes by providing transcription factor binding sites (TFBS). RE-linked TFBS profile can serve as a marker of gene transcriptional regulation evolution. This approach allows for interrogating the regulatory evolution of organisms with RE-rich genomes. We aimed to characterize the evolution of transcriptional regulation for human genes and molecular pathways using RE-linked TFBS accumulation as a metric.

Sections du résumé

BACKGROUND
Retroelements (REs) are transposable elements occupying ~40% of the human genome that can regulate genes by providing transcription factor binding sites (TFBS). RE-linked TFBS profile can serve as a marker of gene transcriptional regulation evolution. This approach allows for interrogating the regulatory evolution of organisms with RE-rich genomes. We aimed to characterize the evolution of transcriptional regulation for human genes and molecular pathways using RE-linked TFBS accumulation as a metric.

Identifiants

pubmed: 30736359
pii: cells8020130
doi: 10.3390/cells8020130
pmc: PMC6406739
pii:
doi:

Substances chimiques

Retroelements 0
Transcription Factors 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Commentaires et corrections

Type : ErratumIn

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Auteurs

Daniil Nikitin (D)

I.M. Sechenov First Moscow State Medical University, Moscow 119991, Russia. danya.nikitin.orel@gmail.com.
Omicsway Corp., Walnut, CA 91798, USA. danya.nikitin.orel@gmail.com.
Faculty of Biology, Moscow State University, Moscow 119192, Russia. danya.nikitin.orel@gmail.com.

Andrew Garazha (A)

Omicsway Corp., Walnut, CA 91798, USA. garazha@oncobox.com.
D. Rogachev Federal Research Center of Pediatric Hematology, Oncology and Immunology, Moscow 117198, Russia. garazha@oncobox.com.

Maxim Sorokin (M)

I.M. Sechenov First Moscow State Medical University, Moscow 119991, Russia. sorokin@oncobox.com.
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow 117198, Russia. sorokin@oncobox.com.

Dmitry Penzar (D)

Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow 119992, Russia. dmitrypenzar1996@gmail.com.

Victor Tkachev (V)

Omicsway Corp., Walnut, CA 91798, USA. tkachev@oncobox.com.

Alexander Markov (A)

Faculty of Biology, Moscow State University, Moscow 119192, Russia. markov_a@inbox.ru.

Nurshat Gaifullin (N)

Faculty of Fundamental Medicine, Moscow State University, Moscow 119992, Russia. gaifulin@rambler.ru.

Pieter Borger (P)

Laboratory of the Swiss Hepato-Pancreato-Biliary (HPB) and Transplantation Center, Department of Surgery, University Hospital Zürich, Raemistrasse 100, Zürich CH-8091, Switzerland. pieter.borger@usz.ch.

Alexander Poltorak (A)

Program in Immunology, Sackler Graduate School, Tufts University, Boston, MA 02111, USA. alexander.poltorak@tufts.edu.

Anton Buzdin (A)

I.M. Sechenov First Moscow State Medical University, Moscow 119991, Russia. buzdin@oncobox.com.
Omicsway Corp., Walnut, CA 91798, USA. buzdin@oncobox.com.
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow 117198, Russia. buzdin@oncobox.com.

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Classifications MeSH