Chimeric Antigen Receptor T-Cells: The Future is Now.
Chimeric
T cell
cellular
immunotherapy
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
07 Feb 2019
07 Feb 2019
Historique:
received:
15
01
2019
revised:
29
01
2019
accepted:
31
01
2019
entrez:
10
2
2019
pubmed:
10
2
2019
medline:
10
2
2019
Statut:
epublish
Résumé
The immune system acting via cancer immune-surveillance is considered a potential target for improving outcomes among some malignancies. The ability to harness immune cells, engineer them and educate them to target cancer cells has changed the paradigm for treating non-Hodgkin's lymphomas (NHL) and acute lymphoblastic leukemia (ALL). Chimeric antigen receptor (CAR) T-cell therapy has shown remarkable anti-tumor activity against refractory B cell malignancies. Ongoing research aims to expand the scope of this adoptive cell therapy, understanding mechanisms of resistance and reducing toxicity. In this review, we will discuss the current scope of CAR T-cell therapy and ongoing future applications.
Identifiants
pubmed: 30736426
pii: jcm8020207
doi: 10.3390/jcm8020207
pmc: PMC6406995
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Immunol Rev. 2014 Jan;257(1):107-26
pubmed: 24329793
Cancer Lett. 2013 Jul 1;334(2):237-44
pubmed: 22902507
Nat Med. 2018 Oct;24(10):1504-1506
pubmed: 30275569
Biol Blood Marrow Transplant. 2010 Sep;16(9):1245-56
pubmed: 20304086
Sci Transl Med. 2017 Jan 25;9(374):
pubmed: 28123068
Blood. 2017 Nov 23;130(21):2295-2306
pubmed: 28924019
Nat Rev Drug Discov. 2016 Apr;15(4):235-47
pubmed: 26965203
Leukemia. 2017 Oct;31(10):2191-2199
pubmed: 28202953
Blood. 2000 Sep 1;96(5):1999-2001
pubmed: 10961908
Biomark Res. 2017 Jun 24;5:22
pubmed: 28652918
J Hematol Oncol. 2018 Nov 27;11(1):132
pubmed: 30482221
Cancer Res. 2007 Jun 15;67(12):5957-64
pubmed: 17575166
Nat Med. 2018 Oct;24(10):1499-1503
pubmed: 30275568
Cancer Discov. 2015 Dec;5(12):1282-95
pubmed: 26516065
N Engl J Med. 2018 Feb 1;378(5):439-448
pubmed: 29385370
Mol Ther. 2012 Mar;20(3):633-43
pubmed: 22127019
Blood. 2007 Feb 1;109(3):944-50
pubmed: 17032921
Blood. 2013 Dec 12;122(25):4129-39
pubmed: 24055823
Cancer J. 2014 Mar-Apr;20(2):127-33
pubmed: 24667958
Sci Transl Med. 2014 Feb 19;6(224):224ra25
pubmed: 24553386
Cancer Immunol Res. 2013 Jul;1(1):26-31
pubmed: 24777247
N Engl J Med. 2016 Dec 29;375(26):2561-9
pubmed: 28029927
Cancer Discov. 2018 Oct;8(10):1219-1226
pubmed: 30135176
Blood. 2017 Jun 22;129(25):3322-3331
pubmed: 28408462
N Engl J Med. 2018 Jul 5;379(1):64-73
pubmed: 29972754
Biochem Soc Trans. 2016 Apr 15;44(2):412-8
pubmed: 27068948
N Engl J Med. 2014 Oct 16;371(16):1507-17
pubmed: 25317870
Blood. 2018 Jun 14;131(24):2621-2629
pubmed: 29728402
Lancet. 2015 Feb 7;385(9967):517-528
pubmed: 25319501
Oncoimmunology. 2015 Jan 23;4(3):e994446
pubmed: 25949921
J Immunother Cancer. 2017 Mar 21;5:28
pubmed: 28331617
Leuk Lymphoma. 2018 Aug;59(8):1785-1796
pubmed: 29058502
J Clin Invest. 2016 Jun 1;126(6):2123-38
pubmed: 27111235
J Exp Med. 1998 Aug 17;188(4):619-26
pubmed: 9705944
Sci Transl Med. 2016 Sep 7;8(355):355ra116
pubmed: 27605551
Nat Med. 2018 Oct;24(10):1492-1493
pubmed: 30297897
Mol Ther Oncolytics. 2016 Apr 20;3:16011
pubmed: 27626062
J Clin Oncol. 2015 Sep 20;33(27):2938-48
pubmed: 26304874
Mol Ther. 2013 Apr;21(4):904-12
pubmed: 23423337
Cancer Cell. 2017 Apr 10;31(4):476-485
pubmed: 28366678
Ther Adv Hematol. 2015 Oct;6(5):228-41
pubmed: 26425336
Mol Cell Biol. 2018 Oct 15;38(21):
pubmed: 30104252
Leukemia. 2018 Nov;32(11):2307-2315
pubmed: 30315238
Nat Rev Clin Oncol. 2018 Jan;15(1):47-62
pubmed: 28925994
Mol Ther. 2013 Mar;21(3):629-37
pubmed: 23070117
Cancer Discov. 2017 Dec;7(12):1404-1419
pubmed: 29025771
J Clin Invest. 2007 May;117(5):1137-46
pubmed: 17476343
Cancer Immunol Immunother. 2017 Nov;66(11):1425-1436
pubmed: 28660319
J Clin Oncol. 2006 May 1;24(13):e20-2
pubmed: 16648493
J Clin Oncol. 2017 Jun 1;35(16):1803-1813
pubmed: 28291388
N Engl J Med. 2018 Feb 1;378(5):449-459
pubmed: 29385376
N Engl J Med. 2017 Dec 28;377(26):2531-2544
pubmed: 29226797
Blood. 2016 Jun 30;127(26):3321-30
pubmed: 27207799
N Engl J Med. 2013 Apr 18;368(16):1509-1518
pubmed: 23527958