Patterns of Genomic Instability in Breast Cancer.

Breast Neoplasms / genetics Disease Progression Female Genomic Instability Humans
breast cancer genomic instability mutation signatures

Journal

Trends in pharmacological sciences
ISSN: 1873-3735
Titre abrégé: Trends Pharmacol Sci
Pays: England
ID NLM: 7906158

Informations de publication

Date de publication:
03 2019
Historique:
received: 30 09 2018
revised: 14 12 2018
accepted: 08 01 2019
pubmed: 10 2 2019
medline: 7 3 2019
entrez: 10 2 2019
Statut: ppublish

Résumé

Breast cancer is one of the most common cancers affecting women. Despite significant improvements in overall survival, it remains a significant cause of death worldwide. Genomic instability (GI) is a hallmark of cancer and plays a pivotal role in breast cancer development and progression. In the past decade, high-throughput technologies have provided a wealth of information that has facilitated the identification of a diverse repertoire of mutated genes and mutational processes operative across cancers. Here, we review recent findings on genomic alterations and mutational processes in breast cancer pathogenesis. Most importantly, we summarize the clinical challenges and opportunities to utilize omics-based signatures for better management of breast cancer patients and treatment decision-making.

Identifiants

DOI: 10.1016/j.tips.2019.01.005 PMID: 30736983
pubmed: 30736983
pii: S0165-6147(19)30016-1
doi: 10.1016/j.tips.2019.01.005
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

198-211

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Murugan Kalimutho (M)

QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, QLD 4006, Australia. Electronic address: Murugan.Kalimutho@qimrberghofer.edu.au.

Katia Nones (K)

QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, QLD 4006, Australia.

Sriganesh Srihari (S)

Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia.

Pascal H G Duijf (PHG)

University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, 37 Kent Street, Brisbane, QLD 4102, Australia.

Nicola Waddell (N)

QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, QLD 4006, Australia.

Kum Kum Khanna (KK)

QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, QLD 4006, Australia. Electronic address: KumKum.Khanna@qimrberghofer.edu.au.

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Classifications MeSH

questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Patterns of Genomic Instability in Breast Cancer.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › Patterns of Genomic Instability in Breast Cancer.
questionsmedicales.fr › Phénomènes génétiques › Instabilité du génome › Patterns of Genomic Instability in Breast Cancer.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Patterns of Genomic Instability in Breast Cancer.