Implication of oxidative stress in the pathogenesis of systemic sclerosis via inflammation, autoimmunity and fibrosis.
Journal
Redox biology
ISSN: 2213-2317
Titre abrégé: Redox Biol
Pays: Netherlands
ID NLM: 101605639
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
16
11
2018
revised:
22
01
2019
accepted:
23
01
2019
pubmed:
10
2
2019
medline:
24
4
2020
entrez:
10
2
2019
Statut:
ppublish
Résumé
Systemic sclerosis is an autoimmune disorder characterized by inflammation and a progressive fibrosis affecting the skin and visceral organs. Over the last two decades, it became clear that oxidative stress plays a key role in its pathogenesis. In this review, we highlighted the role of ROS in the various pathological components of systemic sclerosis, namely the inflammatory, the autoimmune and the fibrotic processes. We also discussed how these pathological processes can induce ROS overproduction, thus maintaining a vicious circle. Finally, we summarized the therapeutic approaches targeting oxidative stress tested in systemic sclerosis, in cells, animal models and patients.
Identifiants
pubmed: 30737171
pii: S2213-2317(18)31091-7
doi: 10.1016/j.redox.2019.101122
pmc: PMC6859527
pii:
doi:
Substances chimiques
Reactive Oxygen Species
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
101122Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.