Clinical significance of non-culprit plaque regression following acute coronary syndrome: A serial intravascular ultrasound study.
Acute Coronary Syndrome
/ etiology
Aged
Cholesterol, LDL
/ blood
Combined Modality Therapy
Coronary Artery Disease
/ blood
Female
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors
/ therapeutic use
Male
Middle Aged
Percutaneous Coronary Intervention
/ methods
Proportional Hazards Models
Prospective Studies
Retrospective Studies
Treatment Outcome
Ultrasonography, Interventional
/ methods
Acute coronary syndrome
Low-density lipoprotein cholesterol
Plaque regression
Serial intravascular ultrasound
Journal
Journal of cardiology
ISSN: 1876-4738
Titre abrégé: J Cardiol
Pays: Netherlands
ID NLM: 8804703
Informations de publication
Date de publication:
Aug 2019
Aug 2019
Historique:
received:
05
11
2018
revised:
15
12
2018
accepted:
30
12
2018
pubmed:
10
2
2019
medline:
26
6
2020
entrez:
10
2
2019
Statut:
ppublish
Résumé
The use of serial intravascular ultrasound (IVUS) for coronary atherosclerosis has offered valuable insight into plaque regression (PR) or progression. However, the beneficial effects of PR on the long-term clinical outcomes in patients with acute coronary syndrome (ACS) remain unclear. We aimed to evaluate the impact of coronary plaque change in patients following primary percutaneous coronary intervention. We retrospectively analyzed data from 4 prospective clinical trials involving 173 patients with ACS who underwent serial IVUS of non-culprit lesions on statin treatment at baseline and at 6 or 8 months of follow-up. The relationship of the IVUS findings with the change in percent atheroma volume (PAV), on-treatment low-density lipoprotein cholesterol (LDL-C), and major adverse cardiac and cerebrovascular events (MACCE) were investigated. In our serial IVUS analysis, baseline plaque volume and PAV were 79.6mm Achievement of both PR and sufficient lowering of the LDL-C was clinically important in post-ACS management.
Sections du résumé
BACKGROUND
BACKGROUND
The use of serial intravascular ultrasound (IVUS) for coronary atherosclerosis has offered valuable insight into plaque regression (PR) or progression. However, the beneficial effects of PR on the long-term clinical outcomes in patients with acute coronary syndrome (ACS) remain unclear. We aimed to evaluate the impact of coronary plaque change in patients following primary percutaneous coronary intervention.
METHODS
METHODS
We retrospectively analyzed data from 4 prospective clinical trials involving 173 patients with ACS who underwent serial IVUS of non-culprit lesions on statin treatment at baseline and at 6 or 8 months of follow-up. The relationship of the IVUS findings with the change in percent atheroma volume (PAV), on-treatment low-density lipoprotein cholesterol (LDL-C), and major adverse cardiac and cerebrovascular events (MACCE) were investigated.
RESULTS
RESULTS
In our serial IVUS analysis, baseline plaque volume and PAV were 79.6mm
CONCLUSIONS
CONCLUSIONS
Achievement of both PR and sufficient lowering of the LDL-C was clinically important in post-ACS management.
Identifiants
pubmed: 30737184
pii: S0914-5087(19)30011-5
doi: 10.1016/j.jjcc.2018.12.023
pii:
doi:
Substances chimiques
Cholesterol, LDL
0
Hydroxymethylglutaryl-CoA Reductase Inhibitors
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
102-108Informations de copyright
Copyright © 2019 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.