Ces1d deficiency protects against high-sucrose diet-induced hepatic triacylglycerol accumulation.
carboxylesterase 1d
lipogenesis
liver
nonalcoholic fatty liver disease
Journal
Journal of lipid research
ISSN: 1539-7262
Titre abrégé: J Lipid Res
Pays: United States
ID NLM: 0376606
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
16
01
2019
pubmed:
10
2
2019
medline:
1
7
2020
entrez:
10
2
2019
Statut:
ppublish
Résumé
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. Triacylglycerol accumulation in the liver is a hallmark of NAFLD. Metabolic studies have confirmed that increased hepatic de novo lipogenesis (DNL) in humans contributes to fat accumulation in the liver and to NAFLD progression. Mice deficient in carboxylesterase (Ces)1d expression are protected from high-fat diet-induced hepatic steatosis. To investigate whether loss of Ces1d can also mitigate steatosis induced by over-activated DNL, WT and Ces1d-deficient mice were fed a lipogenic high-sucrose diet (HSD). We found that Ces1d-deficient mice were protected from HSD-induced hepatic lipid accumulation. Mechanistically, Ces1d deficiency leads to activation of AMP-activated protein kinase and inhibitory phosphorylation of acetyl-CoA carboxylase. Together with our previous demonstration that Ces1d deficiency attenuated high-fat diet-induced steatosis, this study suggests that inhibition of CES1 (the human ortholog of Ces1d) might represent a novel pharmacological target for prevention and treatment of NAFLD.
Identifiants
pubmed: 30737251
pii: S0022-2275(20)32600-6
doi: 10.1194/jlr.M092544
pmc: PMC6446703
pii:
doi:
Substances chimiques
Triglycerides
0
Sucrose
57-50-1
Carboxylesterase
EC 3.1.1.1
Ces1d protein, mouse
EC 3.1.1.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
880-891Subventions
Organisme : CIHR
ID : MOP-69043
Pays : Canada
Informations de copyright
Copyright © 2019 Lian et al.
Références
Biochem J. 1999 Mar 15;338 ( Pt 3):761-8
pubmed: 10051450
Biochem J. 1999 Oct 1;343 Pt 1:1-10
pubmed: 10493905
Genes Dev. 2000 Nov 15;14(22):2819-30
pubmed: 11090130
Biochim Biophys Acta. 2001 Jun 29;1532(3):162-72
pubmed: 11470237
J Mol Biol. 2002 Mar 22;317(2):309-23
pubmed: 11902845
Am J Clin Nutr. 2003 Jan;77(1):43-50
pubmed: 12499321
FASEB J. 2003 Sep;17(12):1685-7
pubmed: 12958176
Biochem J. 2004 Mar 15;378(Pt 3):967-74
pubmed: 14662008
J Biol Chem. 2004 May 7;279(19):20314-26
pubmed: 14985368
J Lipid Res. 2004 Jun;45(6):1122-31
pubmed: 14993246
J Biol Chem. 2004 Jun 11;279(24):25164-71
pubmed: 15066988
Mol Biol Cell. 2005 Feb;16(2):984-96
pubmed: 15601899
J Clin Invest. 2005 May;115(5):1343-51
pubmed: 15864352
Hepatology. 2005 Jul;42(1):44-52
pubmed: 15895401
Nature. 2007 Jan 11;445(7124):219-23
pubmed: 17187055
J Biol Chem. 2007 Mar 16;282(11):8027-35
pubmed: 17237500
Annu Rev Nutr. 2007;27:79-101
pubmed: 17313320
Int J Biochem. 1992 Feb;24(2):249-53
pubmed: 1733790
Diabetes. 2007 Oct;56(10):2523-32
pubmed: 17646209
J Biol Chem. 2008 May 9;283(19):13087-99
pubmed: 18337240
J Biol Chem. 2010 Jan 15;285(3):1607-15
pubmed: 19933273
Cell Metab. 2010 Mar 3;11(3):183-93
pubmed: 20197051
Circulation. 2010 Mar 23;121(11):1356-64
pubmed: 20308626
Am J Physiol Renal Physiol. 2012 Apr 15;302(8):F943-56
pubmed: 21937605
Hepatology. 2012 Jul;56(1):95-107
pubmed: 22278400
Nature. 2012 Apr 19;484(7394):333-8
pubmed: 22466288
Hepatology. 2012 Dec;56(6):2154-62
pubmed: 22707181
Can J Public Health. 2012 May-Jun;103(3):178-82
pubmed: 22905635
Diabetes. 2014 Mar;63(3):934-46
pubmed: 24194501
Eur J Nutr. 2014 Jun;53(4):1103-14
pubmed: 24197180
Nat Chem Biol. 2014 Feb;10(2):113-21
pubmed: 24362705
Hepatology. 2015 Mar;61(3):870-82
pubmed: 25179419
Hepatology. 2015 Apr;61(4):1227-38
pubmed: 25418138
Nat Cell Biol. 2015 Jun;17(6):759-70
pubmed: 25961502
Eur J Biochem. 1989 Dec 8;186(1-2):129-36
pubmed: 2598924
Hepatobiliary Surg Nutr. 2015 Apr;4(2):109-16
pubmed: 26005677
Hepatology. 2016 Jul;64(1):73-84
pubmed: 26707365
Cell Metab. 2016 Feb 9;23(2):335-43
pubmed: 26724858
Autophagy. 2016;12(2):432-8
pubmed: 26902588
Sci Rep. 2016 May 16;6:25747
pubmed: 27181051
Cell Rep. 2017 Mar 28;18(13):3043-3051
pubmed: 28355557
Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Oct;1862(10 Pt B):1197-1204
pubmed: 28648584
Protein Cell. 2018 Feb;9(2):178-195
pubmed: 28677105
Cell Metab. 2017 Aug 1;26(2):324-341
pubmed: 28768172
J Nutr Biochem. 2017 Nov;49:71-79
pubmed: 28886439
FEBS Lett. 1987 Nov 2;223(2):217-22
pubmed: 2889619
Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Jul;1863(7):688-699
pubmed: 29631096
FASEB J. 1995 Apr;9(7):541-6
pubmed: 7737463
Proc Natl Acad Sci U S A. 1993 Oct 15;90(20):9261-5
pubmed: 8415689
Metabolism. 1996 Dec;45(12):1547-50
pubmed: 8969290
Biochemistry. 1997 Feb 18;36(7):1861-8
pubmed: 9048571
Am J Clin Nutr. 1998 Apr;67(4):631-9
pubmed: 9537610