Zinc-oxide nanoparticles act catalytically and synergistically with nitric oxide donors to enhance antimicrobial efficacy.
3T3 Cells
Animals
Anti-Bacterial Agents
/ pharmacology
Bacterial Adhesion
/ drug effects
Catalysis
Cell Survival
/ drug effects
Kinetics
Mice
Microbial Sensitivity Tests
Microbial Viability
/ drug effects
Nanoparticles
/ chemistry
Nitric Oxide
/ metabolism
Nitric Oxide Donors
/ pharmacology
S-Nitroso-N-Acetylpenicillamine
/ pharmacology
Spectrometry, X-Ray Emission
Zinc Oxide
/ pharmacology
antimicrobial
catalysis
medical device coating
nitric oxide
zinc oxide nanoparticle
Journal
Journal of biomedical materials research. Part A
ISSN: 1552-4965
Titre abrégé: J Biomed Mater Res A
Pays: United States
ID NLM: 101234237
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
15
10
2018
revised:
26
11
2018
accepted:
29
01
2019
pubmed:
10
2
2019
medline:
7
8
2020
entrez:
10
2
2019
Statut:
ppublish
Résumé
The development of infection-resistant materials is of substantial importance as seen with an increase in antibiotic resistance. In this project, the nitric oxide (NO)-releasing polymer has an added topcoat of zinc oxide nanoparticle (ZnO-NP) to improve NO-release and match the endogenous NO flux (0.5-4 × 10
Identifiants
pubmed: 30737882
doi: 10.1002/jbm.a.36657
pmc: PMC6527449
mid: NIHMS1017841
doi:
Substances chimiques
Anti-Bacterial Agents
0
Nitric Oxide Donors
0
Nitric Oxide
31C4KY9ESH
S-Nitroso-N-Acetylpenicillamine
79032-48-7
Zinc Oxide
SOI2LOH54Z
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1425-1433Subventions
Organisme : NHLBI NIH HHS
ID : K25 HL111213
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL134899
Pays : United States
Organisme : NHLBI NIH HHS
ID : K25HL111213
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01HL134899
Pays : United States
Informations de copyright
© 2019 Wiley Periodicals, Inc.
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