A false positive case of high-sensitivity cardiac troponin in a patient with acute chest pain: Analytical study of the interference.
Cardiac troponin
Heterophile antibodies
Immunoassay
Interference
Journal
Clinical biochemistry
ISSN: 1873-2933
Titre abrégé: Clin Biochem
Pays: United States
ID NLM: 0133660
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
05
12
2018
revised:
29
01
2019
accepted:
03
02
2019
pubmed:
10
2
2019
medline:
23
4
2019
entrez:
10
2
2019
Statut:
ppublish
Résumé
We report a case of a heterophile antibodies interference in a new high-sensitivity troponin commercial immunoassay (cTNIH Siemens), observed in a patient with possible acute coronary syndrome (ACS). The analytical interference was investigated with standard laboratories procedures. The false positive result was found with different troponin methods and kits. We also investigated the protein sequence of cTnl and no sequence variants were detected. The discordance between clinical pictures and high concentration of cTnl, together with the collaboration between clinicians and laboratory staff avoided possible erroneous diagnosis and further invasive investigations to the patient.
Identifiants
pubmed: 30738031
pii: S0009-9120(18)31330-4
doi: 10.1016/j.clinbiochem.2019.02.002
pii:
doi:
Substances chimiques
Antibodies, Heterophile
0
Antibodies, Monoclonal
0
Troponin I
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
103-105Informations de copyright
Copyright © 2019 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.