Partial volume effect of SPECT images in PRRT with 177Lu labelled somatostatin analogues: A practical solution.
Partial volume correction
Partial volume effect
Quantitative imaging
Recovery coefficient
SPECT
Journal
Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)
ISSN: 1724-191X
Titre abrégé: Phys Med
Pays: Italy
ID NLM: 9302888
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
29
06
2018
revised:
26
11
2018
accepted:
20
12
2018
entrez:
11
2
2019
pubmed:
11
2
2019
medline:
15
3
2019
Statut:
ppublish
Résumé
At present activity quantification is one of the most critical step in dosimetry calculation, and Partial Volume Effect (PVE) one of the most important source of error. In recent years models based upon phantoms that incorporate hot spheres have been used to establish recovery models. In this context the goal of this study was to point out the most critical issues related to PVE and to establish a model closer to a biological imaging environment. Two different phantoms, filled with a The RCs versus volume of the inserts produced two different curves, one for the spheres and one for the organs. After PVE correction, accuracy on activity quantification averaged over all inserts of three test phantoms passed from -26% to 1.3% (from 26% to 10% for absolute values). RCs is a simple method for PVE correction easily applicable in clinical routine. The use of two different models for organs and lesions has permitted to closely mimic the situation in a living subject. A marked improvement in the quantification of activity was observed when PVE correction was adopted, even if further investigations should be performed for more accurate models of PVE corrections.
Sections du résumé
BACKGROUND
BACKGROUND
At present activity quantification is one of the most critical step in dosimetry calculation, and Partial Volume Effect (PVE) one of the most important source of error. In recent years models based upon phantoms that incorporate hot spheres have been used to establish recovery models. In this context the goal of this study was to point out the most critical issues related to PVE and to establish a model closer to a biological imaging environment.
METHODS
METHODS
Two different phantoms, filled with a
RESULTS
RESULTS
The RCs versus volume of the inserts produced two different curves, one for the spheres and one for the organs. After PVE correction, accuracy on activity quantification averaged over all inserts of three test phantoms passed from -26% to 1.3% (from 26% to 10% for absolute values).
CONCLUSION
CONCLUSIONS
RCs is a simple method for PVE correction easily applicable in clinical routine. The use of two different models for organs and lesions has permitted to closely mimic the situation in a living subject. A marked improvement in the quantification of activity was observed when PVE correction was adopted, even if further investigations should be performed for more accurate models of PVE corrections.
Identifiants
pubmed: 30738519
pii: S1120-1797(18)31365-6
doi: 10.1016/j.ejmp.2018.12.029
pii:
doi:
Substances chimiques
177Lu-octreotide, DOTA(0)-Tyr(3)-
0
Receptors, Somatostatin
0
Octreotide
RWM8CCW8GP
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
153-159Informations de copyright
Copyright © 2019 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.