Chenopodium ambrosioides induces an endothelium-dependent relaxation of rat isolated aorta.
Ca(2+)-activated potassium channels
Chenopodiaceae
Chenopodium ambrosioides
Complementary and alternative medicine
High-performance liquid chromatography
Plant
Thin-layer chromatography
Vasorelaxation
Journal
Journal of integrative medicine
ISSN: 2095-4964
Titre abrégé: J Integr Med
Pays: Netherlands
ID NLM: 101603118
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
01
06
2018
accepted:
27
12
2018
pubmed:
11
2
2019
medline:
17
4
2020
entrez:
11
2
2019
Statut:
ppublish
Résumé
This study aims to evaluate the vasodilatory effect of Chenopodium ambrosioides on the isolated rat aorta, and to explore its mechanism of action. The vasorelaxant effect and the mode of action of various extracts from the leaves of C. ambrosioides were evaluated on thoracic aortic rings isolated from Wistar rats. In addition, ethyl acetate and methanol fractions were analyzed, using thin-layer chromatography and high-performance liquid chromatography techniques, for their polyphenolic content. The various active extracts of C. ambrosioides at four concentrations (10 These results suggest that the MF of C. ambrosioides produces an endothelium-dependent relaxation of the isolated rat aorta, which is thought to be mediated mainly through stimulation of the muscarinic receptors, and probably involving the opening of Ca
Identifiants
pubmed: 30738772
pii: S2095-4964(19)30006-8
doi: 10.1016/j.joim.2019.01.006
pii:
doi:
Substances chimiques
Plant Extracts
0
Vasodilator Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
115-124Informations de copyright
Copyright © 2019 Shanghai Changhai Hospital. Published by Elsevier B.V. All rights reserved.