Genetic contribution of catechol-O-methyltransferase in dorsolateral prefrontal cortex functional changes in the first episode schizophrenia.
Adult
Asian People
/ genetics
Brain
/ pathology
Brain Mapping
/ methods
Case-Control Studies
Catechol O-Methyltransferase
/ genetics
Cerebral Cortex
/ physiopathology
China
Female
Genotype
Gyrus Cinguli
/ physiopathology
Humans
Magnetic Resonance Imaging
/ methods
Male
Parietal Lobe
/ physiopathology
Polymorphism, Single Nucleotide
/ genetics
Prefrontal Cortex
/ metabolism
Psychotic Disorders
/ physiopathology
Schizophrenia
/ genetics
Young Adult
Catechol-O-methyltransferase
Dorsolateral prefrontal cortex
First episode schizophrenia
Negative symptoms
Resting state functional connectivity
Journal
Behavioural brain research
ISSN: 1872-7549
Titre abrégé: Behav Brain Res
Pays: Netherlands
ID NLM: 8004872
Informations de publication
Date de publication:
17 05 2019
17 05 2019
Historique:
received:
23
10
2018
revised:
15
01
2019
accepted:
05
02
2019
pubmed:
11
2
2019
medline:
14
2
2020
entrez:
11
2
2019
Statut:
ppublish
Résumé
Catechol-O-methyltransferase (COMT) gene variants have been reported to be implicated in the pathogenesis of psychotic symptoms in schizophrenia, especially in negative symptoms. These symptoms including apathy, blunted affect, social withdrawal and motor retardation. Neuroimaging studies suggested that negative symptoms appear to be associated with impaired activities of the prefrontal cortex in particular the dorsolateral prefrontal cortex (DLPFC). Given that the COMT gene is highly expressed in the DLPFC, it is poorly understood whether the disease state and COMT val
Identifiants
pubmed: 30738913
pii: S0166-4328(18)31500-6
doi: 10.1016/j.bbr.2019.02.012
pii:
doi:
Substances chimiques
COMT protein, human
EC 2.1.1.6
Catechol O-Methyltransferase
EC 2.1.1.6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
225-232Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.