Effects of stanniocalcin hormones on rat brown adipose tissue metabolism under fed and fasted conditions.
Journal
Molecular and cellular endocrinology
ISSN: 1872-8057
Titre abrégé: Mol Cell Endocrinol
Pays: Ireland
ID NLM: 7500844
Informations de publication
Date de publication:
05 04 2019
05 04 2019
Historique:
received:
31
10
2018
revised:
23
01
2019
accepted:
04
02
2019
pubmed:
11
2
2019
medline:
18
12
2019
entrez:
11
2
2019
Statut:
ppublish
Résumé
In this study we determined the effect of fed and fasting (48 h) states on the expression of stanniocalcin-1 (Stc1) and stanniocalcin-2 (Stc2) in rat brown adipose tissue (BAT), as well as the in vitro effects of human stanniocalcin 1 and 2 (hSTC-1 and hSTC-2) hormones on lipid and glucose metabolism. In addition, lactate, glycogen levels and hexokinase (HK) activity were determined. In fasting Stc2 expression increased markedly. The targets of action of hSTC-1 and hSTC-2 were glucose uptake and oxidation as well as glycogen storage, controlling the energetic metabolism in BAT. The reduction in glycogen concentration induced by hSTC-2 in fed state might have deleterious consequences in BAT, such as decreased thermogenic activity, FA esterification and other adipocyte functions. On the other hand, the increase of glucose uptake caused by hSTC-1 of fed rats could play a role as a plasma glucose-clearing hormone in the postprandial period.
Identifiants
pubmed: 30738951
pii: S0303-7207(19)30048-6
doi: 10.1016/j.mce.2019.02.004
pii:
doi:
Substances chimiques
Glycoproteins
0
Intercellular Signaling Peptides and Proteins
0
STC2 protein, human
0
Stc2 protein, rat
0
teleocalcin
76687-96-2
Glycogen
9005-79-2
Hexokinase
EC 2.7.1.1
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
81-87Informations de copyright
Copyright © 2019. Published by Elsevier B.V.