Association and interaction of genetic variants with occurrence of ischemic stroke among Brazilian patients.
Case-control study
Genetic association study
Genetic interactions
Genetic variants
Ischemic stroke
Journal
Gene
ISSN: 1879-0038
Titre abrégé: Gene
Pays: Netherlands
ID NLM: 7706761
Informations de publication
Date de publication:
05 May 2019
05 May 2019
Historique:
received:
15
09
2018
revised:
17
12
2018
accepted:
22
01
2019
pubmed:
11
2
2019
medline:
23
3
2019
entrez:
11
2
2019
Statut:
ppublish
Résumé
Ischemic Stroke (IS) is a severe and complex disorder of high morbidity and mortality rates associated with clinical, environmental, and genetic predisposing factors. Despite previous studies have associated genetic variants to stroke, inconsistent results from different populations pointed to the genetic heterogeneity for IS. Therefore, we may hypothesize that an interaction effect among genetic variants could contribute to IS occurrence rather than genetic variants independently. In this context, we investigated the association and interaction between genetic variants and large-artery atherosclerosis IS (LAAS-IS) and cardioembolic IS (CE-IS). We genotyped 435 patients (195 LAAS-IS; 240 CE-IS) and 535 controls from a population of Joinville, Santa Catarina, Brazil. Association and interaction analysis were performed by chi-square test and Multifactor-dimensionality Reduction test. We found an association between rs2383207*A allele, nearby CDKN2B-AS1, and LAAS-IS [OR 2.35 (95% CI = 1.79-3.08); p = 4.66 × 10
Identifiants
pubmed: 30738964
pii: S0378-1119(19)30102-7
doi: 10.1016/j.gene.2019.01.041
pii:
doi:
Substances chimiques
CDKN2B antisense RNA, human
0
RNA, Long Noncoding
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
84-91Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.