Relationship between endogenous melatonin concentrations and uterine contractions in late third trimester of human pregnancy.
circadian
contractions
human
light
melatonin
pregnancy
uterus
Journal
Journal of pineal research
ISSN: 1600-079X
Titre abrégé: J Pineal Res
Pays: England
ID NLM: 8504412
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
31
08
2018
revised:
17
01
2019
accepted:
25
01
2019
pubmed:
11
2
2019
medline:
30
7
2019
entrez:
11
2
2019
Statut:
ppublish
Résumé
In humans, circulating levels of the hormone melatonin and the initiation of spontaneous labor are both higher at night than during the day. Since activation of uterine melatonin receptors can stimulate human in vitro uterine contractions and these receptors are only expressed on the uterine tissue of women in labor, we hypothesized that circulating melatonin concentrations would affect uterine contractions in vivo. We evaluated the impact of light-induced modulation of melatonin secretion on uterine contractions in women during late third trimester (~36-39 weeks) of pregnancy in two inpatient protocols. We found a significant (P < 0.05) positive linear association between circulating melatonin concentrations and the number of uterine contractions under both protocols. On average, uterine contractions increased between 1.4 and 2.1 contractions per 30 minutes for every 10 pg/mL*h increase in melatonin concentration. These findings have both basic science and clinical implications for pregnant women, since endogenous melatonin levels and melatonin receptor activity can be altered by light and/or pharmaceutical agents.
Identifiants
pubmed: 30739346
doi: 10.1111/jpi.12566
pmc: PMC6453747
mid: NIHMS1011293
doi:
Substances chimiques
Receptors, Melatonin
0
Melatonin
JL5DK93RCL
Types de publication
Journal Article
Langues
eng
Pagination
e12566Subventions
Organisme : NHLBI NIH HHS
ID : K24 HL105664
Pays : United States
Organisme : National Institutes of Health
ID : R21-HD086392
Organisme : NHLBI NIH HHS
ID : T32 HL007901
Pays : United States
Organisme : National Institutes of Health
ID : K24-HL105664
Organisme : National Institutes of Health
ID : P01-AG009975
Organisme : NIA NIH HHS
ID : P01 AG009975
Pays : United States
Organisme : National Institutes of Health
ID : T32-HL07901
Organisme : NCATS NIH HHS
ID : UL1 TR001102
Pays : United States
Organisme : National Institutes of Health
ID : UL1-TR001102
Organisme : Harvard Milton Fund
ID : 520.45414.624473.730001.0000.67800
Organisme : NICHD NIH HHS
ID : R21 HD086392
Pays : United States
Informations de copyright
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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