Age-stratified anti-HAV positivity in Pune, India after two decades: Has voluntary vaccination impacted overall exposure to HAV?
Adolescent
Adult
Child
Child, Preschool
Enzyme-Linked Immunosorbent Assay
Female
Hepatitis A
/ epidemiology
Hepatitis A Antibodies
/ blood
Hepatitis A Vaccines
/ administration & dosage
Hepatitis A virus
Humans
Hygiene
India
/ epidemiology
Infant
Infant, Newborn
Male
Middle Aged
Prevalence
Retrospective Studies
Social Class
Vaccination
/ statistics & numerical data
Young Adult
India
anti-HAV positivity
hepatitis A vaccine
socioeconomic status
vaccine age
Journal
Journal of viral hepatitis
ISSN: 1365-2893
Titre abrégé: J Viral Hepat
Pays: England
ID NLM: 9435672
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
18
07
2018
accepted:
18
01
2019
pubmed:
11
2
2019
medline:
23
7
2020
entrez:
11
2
2019
Statut:
ppublish
Résumé
The degree of transmission of hepatitis A virus (HAV) is inversely proportional to the socioeconomic status of a community. Serosurveys conducted at Pune, India during 1982-98 documented significant reduction in HAV exposure of paediatric, higher socioeconomic status (HSS) population. Anti-HAV positivity (ELISA) in age-stratified Pune population representing HSS and lower middle socioeconomic status (LMSS) (n = 1065) and infants till the age of 15 months (n = 690) was determined in 2017. Anti-HAV positivity in the LMSS population decreased significantly in 2017 while an increase was seen in the HSS category. The surprising rise in anti-HAV positivity in the HSS population reflected vaccine- and infection-induced antibodies while only infection-induced antibodies were present in the LMSS category. Lowest antibody prevalence in infants was at 12 months, the recommended age for hepatitis A vaccination. Improved hygiene and selective immunization practices impacted HAV exposure of the LMSS population. The data emphasize the need for hepatitis A vaccination irrespective of socioeconomic status.
Substances chimiques
Hepatitis A Antibodies
0
Hepatitis A Vaccines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
757-760Informations de copyright
© 2019 John Wiley & Sons Ltd.