The Diagnosis and Blistering Mechanisms of Mucous Membrane Pemphigoid.
C-terminas
collagen IV
direct immunofluorescence
mucous membrane pemphigoid
steric hindrance
type XVII collagen
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
16
11
2018
accepted:
08
01
2019
entrez:
12
2
2019
pubmed:
12
2
2019
medline:
21
12
2019
Statut:
epublish
Résumé
Mucous membrane pemphigoid (MMP) is a mucous membrane-dominated autoimmune subepithelial blistering disease that is caused by autoantibodies against various autoantigens in basement membrane zone (BMZ) proteins, including collagen XVII (COL17). Clinicians face diagnostic problems in detecting circulating antibodies and targeted antigens in MMP. The diagnostic difficulties are mainly attributed to the low titers of MMP autoantibodies in sera and to heterogeneous autoantigens. Additionally, no unanimous diagnostic criteria have been drawn for MMP, which can result in delayed diagnoses or misdiagnoses. This review aims to integrate and present currently available data to clarify diagnostic strategies and to present diagnostic criteria for MMP. The ultimate blistering mechanism in MMP has not been elucidated, and such mechanism is especially obscure in COL17-type MMP. In bullous pemphigoid (BP), which is the most common autoimmune subepidermal blistering disease, some patients show oral lesion as well as predominant skin lesions. However, there is no fundamental explanation for the onset of oral lesions in BP. This article summarizes innovative research perspectives on the pathogenesis of oral lesions in pemphigoid. Finally, we propose a potential pathogenesis for COL17-type MMP.
Identifiants
pubmed: 30740099
doi: 10.3389/fimmu.2019.00034
pmc: PMC6357922
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
34Références
Exp Dermatol. 2017 Dec;26(12):1163-1170
pubmed: 28833569
J Invest Dermatol. 2016 May;136(5):938-946
pubmed: 26827765
Br J Dermatol. 2010 Mar;162(3):513-7
pubmed: 19751242
J Invest Dermatol. 1999 Feb;112(2):254-5
pubmed: 9989805
Ophthalmology. 2004 Jan;111(1):45-52
pubmed: 14711713
J Invest Dermatol. 1996 Jan;106(1):141-6
pubmed: 8592065
J Invest Dermatol. 2018 May;138(5):1201-1204
pubmed: 29203362
Acta Derm Venereol. 2018 Jul 11;98(7):660-666
pubmed: 29648673
Eye (Lond). 2018 Sep;32(9):1540-1541
pubmed: 29743586
Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14714-9
pubmed: 8962120
Br J Dermatol. 2001 Nov;145(5):778-83
pubmed: 11736901
J Invest Dermatol. 2018 Aug;138(8):1707-1715
pubmed: 29530535
J Clin Invest. 1997 Sep 1;100(5):1256-63
pubmed: 9276744
J Invest Dermatol. 2000 Jan;114(1):178-84
pubmed: 10620135
Br J Dermatol. 2018 Feb;178(2):e119-e121
pubmed: 28865101
Lab Invest. 2019 Jan;99(1):48-57
pubmed: 30089857
J Immunol. 2000 Sep 1;165(5):2824-9
pubmed: 10946315
J Clin Invest. 1993 Nov;92(5):2480-8
pubmed: 7693763
J Invest Dermatol. 2002 Nov;119(5):1065-73
pubmed: 12445194
Graefes Arch Clin Exp Ophthalmol. 1994 Sep;232(9):533-7
pubmed: 7959092
JAMA Dermatol. 2013 May;149(5):533-40
pubmed: 23426192
Acta Derm Venereol. 2016 Aug 23;96(6):768-73
pubmed: 26631393
Clin Rev Allergy Immunol. 2018 Feb;54(1):26-51
pubmed: 28779299
J Immunol. 2003 Feb 15;170(4):2170-8
pubmed: 12574390
J Dermatol Sci. 2017 Nov;88(2):247-248
pubmed: 28736219
Br J Oral Maxillofac Surg. 2008 Jul;46(5):358-66
pubmed: 17804127
Br J Dermatol. 2016 May;174(5):1022-9
pubmed: 26676445
Exp Dermatol. 2013 Jun;22(6):381-5
pubmed: 23651418
J Clin Invest. 1992 Oct;90(4):1628-33
pubmed: 1401088
Med Mol Morphol. 2016 Jun;49(2):89-97
pubmed: 26658728
Br J Dermatol. 2019 May;180(5):1099-1106
pubmed: 30315657
J Immunol. 2010 Feb 15;184(4):2166-74
pubmed: 20089696
Oral Dis. 2014 Jan;20(1):35-54
pubmed: 24320968
Nat Med. 2007 Mar;13(3):378-83
pubmed: 17322897
J Invest Dermatol. 1997 Nov;109(5):679-83
pubmed: 9347799
J Invest Dermatol. 2017 Aug;137(8):1709-1718
pubmed: 28456612
J Oral Pathol Med. 2019 Jan;48(1):60-67
pubmed: 30222210
Dermatology. 2016;232(2):249-53
pubmed: 26820308
J Am Acad Dermatol. 1994 Jan;30(1):65-75
pubmed: 8277034
J Periodontol. 2014 Jun;85(6):802-9
pubmed: 24592912
J Invest Dermatol. 2005 May;124(5):939-46
pubmed: 15854034
J Invest Dermatol. 2009 Apr;129(4):919-26
pubmed: 19177144
Br J Dermatol. 2006 Jan;154(1):90-8
pubmed: 16403100
J Invest Dermatol. 1987 Aug;89(2):167-71
pubmed: 2439611
Exp Dermatol. 2007 Sep;16(9):770-7
pubmed: 17697150
J Dermatol Sci. 2002 Dec;30(3):224-32
pubmed: 12443845
Orphanet J Rare Dis. 2018 Jul 6;13(1):111
pubmed: 29980216
Front Immunol. 2017 May 31;8:603
pubmed: 28620373
J Invest Dermatol. 1995 Oct;105(4):543-8
pubmed: 7561156
Lancet. 2013 Jan 26;381(9863):320-32
pubmed: 23237497
Front Immunol. 2018 May 24;9:1030
pubmed: 29881377
Br J Dermatol. 2004 Jul;151(1):126-31
pubmed: 15270881
Front Immunol. 2018 Mar 13;9:479
pubmed: 29662486
J Am Acad Dermatol. 2009 Sep;61(3):433-40
pubmed: 19700013
Eur J Dermatol. 2016 Jun 1;26(3):247-53
pubmed: 27193492
J Invest Dermatol. 2006 Dec;126(12):2631-6
pubmed: 16810295
Curr Pharm Des. 2015;21(18):2422-39
pubmed: 25777758
Clin Immunol. 2000 Apr;95(1 Pt 1):26-32
pubmed: 10794429
J Am Acad Dermatol. 1992 Jul;27(1):79-87
pubmed: 1619081
Br J Dermatol. 2018 Nov;179(5):1141-1147
pubmed: 29663327
J Invest Dermatol. 2004 Jan;122(1):103-10
pubmed: 14962097
J Clin Invest. 1995 Apr;95(4):1539-44
pubmed: 7706459
J Am Acad Dermatol. 1991 Jun;24(6 Pt 1):952-8
pubmed: 1869683
J Am Acad Dermatol. 2015 Jan;72(1):168-74
pubmed: 25443626
Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Apr;117(4):483-96
pubmed: 24556492
J Clin Invest. 1996 Oct 1;98(7):1509-18
pubmed: 8833897
Br J Dermatol. 2001 Sep;145(3):406-14
pubmed: 11531829
J Oral Pathol Med. 2018 Jul;47(6):613-619
pubmed: 29752861
J Dermatol Sci. 2017 Mar;85(3):208-215
pubmed: 28012821
Br J Dermatol. 1998 Apr;138(4):602-10
pubmed: 9640363
Eur J Dermatol. 2016 Jan-Feb;26(1):56-63
pubmed: 26771500
Exp Dermatol. 2017 Dec;26(12):1171-1174
pubmed: 28266727
Br J Dermatol. 2019 Jan;180(1):149-156
pubmed: 30216412
Exp Dermatol. 2017 Dec;26(12):1235-1239
pubmed: 28418613
Am J Pathol. 2014 Aug;184(8):2185-96
pubmed: 25043618
Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Aug;120(2):161-71.e20
pubmed: 25953640
Arch Dermatol. 2002 Mar;138(3):370-9
pubmed: 11902988
J Invest Dermatol. 2016 Nov;136(11):2201-2210
pubmed: 27424319
Front Med (Lausanne). 2018 Feb 08;5:20
pubmed: 29473040
J Autoimmun. 2002 Jun;18(4):299-309
pubmed: 12144811
J Am Acad Dermatol. 2017 Oct;77(4):700-705.e3
pubmed: 28676329
J Periodontol. 2004 Oct;75(10):1302-8
pubmed: 15562906
Ophthalmology. 2018 Apr;125(4):496-504
pubmed: 29217149
Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11579-82
pubmed: 1763074