Targeting Tregs in Juvenile Idiopathic Arthritis and Juvenile Dermatomyositis-Insights From Other Diseases.
biomarker
juvenile dermatomyositis
juvenile idiopathic arthritis
regulatory T cells
therapy
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
31
10
2018
accepted:
09
01
2019
entrez:
12
2
2019
pubmed:
12
2
2019
medline:
18
12
2019
Statut:
epublish
Résumé
Regulatory T cells (Tregs) are believed to be dysfunctional in autoimmunity. Juvenile idiopathic arthritis (JIA) and juvenile dermatomyositis (JDM) result from a loss of normal immune regulation in specific tissues such as joints or muscle and skin, respectively. Here, we discuss recent findings in regard to Treg biology in oligo-/polyarticular JIA and JDM, as well as what we can learn about Treg-related disease mechanism, treatment and biomarkers in JIA/JDM from studies of other diseases. We explore the potential use of Treg immunoregulatory markers and gene signatures as biomarkers for disease course and/or treatment success. Further, we discuss how Tregs are affected by several treatment strategies already employed in the therapy of JIA and JDM and by alternative immunotherapies such as anti-cytokine or co-receptor targeting. Finally, we review recent successes in using Tregs as a treatment target with low-dose IL-2 or cellular immunotherapy. Thus, this mini review will highlight our current understanding and identify open questions in regard to Treg biology, and how recent findings may advance biomarkers and new therapies for JIA and JDM.
Identifiants
pubmed: 30740105
doi: 10.3389/fimmu.2019.00046
pmc: PMC6355674
doi:
Substances chimiques
Antibodies, Monoclonal, Humanized
0
Biomarkers
0
Cytokines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
46Subventions
Organisme : Versus Arthritis
ID : 21738
Pays : United Kingdom
Organisme : Versus Arthritis
ID : CDF21738
Pays : United Kingdom
Références
Ann Rheum Dis. 2018 Feb;77(2):e6
pubmed: 28501800
Arthritis Rheumatol. 2018 Jul;70(7):1144-1154
pubmed: 29481737
Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14751-6
pubmed: 20679229
Ann Rheum Dis. 2018 Jan;77(1):55-62
pubmed: 28993346
Am J Transplant. 2016 Jan;16(1):58-71
pubmed: 26414799
Front Immunol. 2018 Mar 23;9:585
pubmed: 29662491
J Autoimmun. 2015 Jan;56:66-80
pubmed: 25457307
Int J Gen Med. 2018 Apr 11;11:151-154
pubmed: 29692623
Expert Rev Mol Diagn. 2015;15(9):1171-86
pubmed: 26289603
Blood. 2011 Jan 20;117(3):1061-70
pubmed: 20952687
Mod Rheumatol. 2018 Nov;28(6):913-921
pubmed: 29669460
J Immunol. 2014 Sep 15;193(6):2699-708
pubmed: 25092890
Ann Rheum Dis. 2017 Aug;76(8):1381-1388
pubmed: 28389553
Ann Rheum Dis. 2016 Jul;75(7):1407-15
pubmed: 26324847
Front Physiol. 2018 Jun 20;9:768
pubmed: 29973887
Expert Rev Mol Med. 2013 Dec 03;15:e13
pubmed: 24294966
Front Immunol. 2018 Feb 13;9:252
pubmed: 29487602
Lancet. 2018 Oct 13;392(10155):1330-1339
pubmed: 30249507
J Clin Immunol. 2011 Aug;31(4):588-95
pubmed: 21487894
Cell Rep. 2015 Sep 29;12(12):1986-96
pubmed: 26387944
J Intern Med. 2016 Jul;280(1):24-38
pubmed: 27028907
Arthritis Rheumatol. 2015 Oct;67(10):2759-70
pubmed: 26097215
Sci Rep. 2018 Aug 13;8(1):12079
pubmed: 30104686
J Immunol. 2018 Oct 1;201(7):2094-2106
pubmed: 30104245
PLoS One. 2015 Apr 10;10(4):e0122198
pubmed: 25860138
J Autoimmun. 2015 Apr;58:48-58
pubmed: 25634360
PLoS One. 2016 May 31;11(5):e0156055
pubmed: 27244050
Arthritis Res Ther. 2013 Apr 08;15(2):211
pubmed: 23566358
Curr Opin Organ Transplant. 2018 Oct;23(5):509-515
pubmed: 30063480
Immunology. 2012 Dec;137(4):305-16
pubmed: 23167249
J Exp Med. 2016 Jun 27;213(7):1241-53
pubmed: 27270893
Sci Transl Med. 2015 Nov 25;7(315):315ra189
pubmed: 26606968
JAMA Dermatol. 2013 Oct;149(10):1204-8
pubmed: 23986394
Am J Pathol. 2009 Mar;174(3):989-98
pubmed: 19218348
Blood. 2016 Feb 25;127(8):1044-51
pubmed: 26563133
Blood. 2011 Sep 29;118(13):3538-48
pubmed: 21828127
Arthritis Rheum. 2011 Oct;63(10):3153-62
pubmed: 21702013
Pediatr Clin North Am. 2018 Aug;65(4):657-674
pubmed: 30031492
Cell. 2018 Aug 9;174(4):968-981.e15
pubmed: 30078711
Nat Rev Immunol. 2009 Dec;9(12):883-9
pubmed: 19935807
Ann N Y Acad Sci. 2009 Dec;1182:97-110
pubmed: 20074279
Blood. 2016 Jul 7;128(1):130-7
pubmed: 27073224
Arthritis Care Res (Hoboken). 2014 May;66(5):783-7
pubmed: 24127327
Nat Med. 2018 Jul;24(7):1005-1014
pubmed: 29942088
Arthritis Rheumatol. 2014 Oct;66(10):2728-38
pubmed: 24965881
J Clin Rheumatol. 2017 Mar;23(2):129-130
pubmed: 28099216
Nat Rev Immunol. 2010 Jul;10(7):490-500
pubmed: 20559327
Arthritis Rheumatol. 2016 Jan;68(1):229-36
pubmed: 26360332
J Immunol. 2015 Dec 15;195(12):5616-24
pubmed: 26561546
Sci Rep. 2018 Jul 3;8(1):10044
pubmed: 29968819
J Clin Rheumatol. 2017 Apr;23(3):174-175
pubmed: 28333871
Arthritis Res Ther. 2013 Aug 30;15(4):R100
pubmed: 24000795
Front Immunol. 2018 Oct 02;9:2273
pubmed: 30333832
PLoS Med. 2016 Oct 11;13(10):e1002139
pubmed: 27727279
J Autoimmun. 2018 May;89:21-29
pubmed: 29146547
J Dermatolog Treat. 2009;20(2):100-8
pubmed: 18923992
Int Arch Allergy Immunol. 2016;171(1):45-53
pubmed: 27820937
Front Immunol. 2017 Mar 06;8:103
pubmed: 28321213
Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):13845-13850
pubmed: 27849614
Diabetes. 2014 Oct;63(10):3449-57
pubmed: 24834977
Diabetes. 2016 Apr;65(4):1031-9
pubmed: 26786322
Nat Med. 2016 Jan;22(1):18-9
pubmed: 26735403
Nat Med. 2016 Jan;22(1):16-7
pubmed: 26735402
Molecules. 2017 Jan 14;22(1):
pubmed: 28098832
Sci Immunol. 2018 Sep 14;3(27):
pubmed: 30217811
Pediatric Health Med Ther. 2016 Sep 19;7:109-120
pubmed: 29388600
Ann Rheum Dis. 2017 Feb;76(2):435-441
pubmed: 27311837
Nat Med. 2015 Jul;21(7):719-29
pubmed: 26121196
Br J Dermatol. 2013 Apr;168(4):844-54
pubmed: 23301632
Best Pract Res Clin Rheumatol. 2017 Aug;31(4):535-557
pubmed: 29773272
Arthritis Rheumatol. 2014 Jul;66(7):1955-60
pubmed: 24692225
J Clin Rheumatol. 2016 Aug;22(5):282-4
pubmed: 27464779
Pediatr Rheumatol Online J. 2018 Jun 20;16(1):39
pubmed: 29925386
ScientificWorldJournal. 2014 Jan 29;2014:179180
pubmed: 24600322
Sci Transl Med. 2013 Apr 3;5(179):179ra43
pubmed: 23552371
Rheumatology (Oxford). 2017 Sep 1;56(9):1542-1551
pubmed: 28582527
PLoS One. 2014 Aug 26;9(8):e105353
pubmed: 25157414
Am J Transplant. 2019 Jan;19(1):62-76
pubmed: 29766641
Blood. 2013 Apr 4;121(14):2647-58
pubmed: 23355538
Arthritis Rheumatol. 2018 Jan;70(1):134-145
pubmed: 28941175
Arthritis Rheum. 2013 Dec;65(12):3259-70
pubmed: 24022275
Sci Transl Med. 2014 Oct 15;6(258):258ra142
pubmed: 25320234
Rheumatology (Oxford). 2015 Sep;54(9):1724-34
pubmed: 25877908
Eur J Immunol. 2015 Feb;45(2):333-43
pubmed: 25378065
J Rheumatol. 2017 Jan;44(1):117-124
pubmed: 27803134
Dis Markers. 2014;2014:472624
pubmed: 24648607
J Clin Invest. 2016 Mar 1;126(3):1039-51
pubmed: 26854929
Arthritis Rheum. 2011 Aug;63(8):2504-15
pubmed: 21381000
Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2509-14
pubmed: 25675517
Pediatr Rheumatol Online J. 2017 Jun 13;15(1):50
pubmed: 28610606
Rev Diabet Stud. 2012 Winter;9(4):359-71
pubmed: 23804273
Lancet. 2008 Aug 2;372(9636):383-91
pubmed: 18632147
Int Rev Immunol. 2018;37(4):206-214
pubmed: 29757670
Arthritis Rheum. 2009 Jul;60(7):2102-12
pubmed: 19565513
Semin Oncol. 2018 Jan;45(1-2):95-104
pubmed: 30318089
Front Immunol. 2018 Jun 26;9:1435
pubmed: 29997618
BMC Med Genomics. 2012 Nov 21;5:53
pubmed: 23171592
J Pediatr. 2012 Mar;160(3):520-2
pubmed: 22244459
Arthritis Care Res (Hoboken). 2015 Dec;67(12):1739-49
pubmed: 26097039
J Immunol. 2018 Nov 1;201(9):2579-2592
pubmed: 30282751
J Immunol. 2018 Oct 1;201(7):1899-1906
pubmed: 30143591
Rheumatology (Oxford). 2016 Apr;55(4):710-20
pubmed: 26672908
J Clin Invest. 2017 Jun 30;127(7):2505-2512
pubmed: 28665300
J Allergy Clin Immunol. 2018 Sep;142(3):978-980.e9
pubmed: 29935955
J Rheumatol. 2014 Dec;41(12):2459-65
pubmed: 25179849
Arthritis Rheum. 2012 Oct;64(10):3129-38
pubmed: 22674488
BioDrugs. 2017 Aug;31(4):299-316
pubmed: 28612180
Arthritis Res Ther. 2017 Jul 5;19(1):158
pubmed: 28679449
Arthritis Rheumatol. 2018 May;70(5):722-735
pubmed: 29342501
Health Technol Assess. 2016 Apr;20(34):1-222
pubmed: 27135404
Arthritis Res Ther. 2016 Apr 01;18:80
pubmed: 27039301
Arthritis Rheumatol. 2016 Jul;68(7):1758-68
pubmed: 26815131
J Immunol Res. 2016;2016:8493767
pubmed: 27144181
Ann N Y Acad Sci. 2018 Apr;1417(1):5-22
pubmed: 26918796
Curr Opin Rheumatol. 2007 Nov;19(6):536-41
pubmed: 17917532
Arthritis Rheum. 2008 Jun;58(6):1609-18
pubmed: 18512781
Ann Rheum Dis. 2018 Feb;77(2):241-250
pubmed: 29084729
Front Immunol. 2013 Jun 19;4:155
pubmed: 23801992
Curr Rheumatol Rep. 2014 Mar;16(3):406
pubmed: 24445961
Blood. 2016 Jan 7;127(1):91-101
pubmed: 26480932
Nat Rev Immunol. 2018 Oct;18(10):648-659
pubmed: 30089912
Arthritis Rheum. 2005 Nov;52(11):3554-62
pubmed: 16255044
Curr Diab Rep. 2016 Jun;16(6):46
pubmed: 27076179
Hum Immunol. 2016 Feb;77(2):201-13
pubmed: 26686412
Data Brief. 2017 May 02;12:676-691
pubmed: 28567438
Cell Mol Immunol. 2019 Jan;16(1):65-74
pubmed: 29375132
Arthritis Res Ther. 2013 Sep 23;15(5):R131
pubmed: 24286299
Ann Rheum Dis. 2007 May;66(5):589-98
pubmed: 17170049