Yes-associated protein promotes early hepatocyte cell cycle progression in regenerating liver after tissue loss.
YAP
cell cycle entry
hepatomegaly
liver function
organ size control
reconstitution
replication
small‐for‐size syndrome
Journal
FASEB bioAdvances
ISSN: 2573-9832
Titre abrégé: FASEB Bioadv
Pays: United States
ID NLM: 101733210
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
20
07
2018
revised:
20
07
2018
accepted:
28
09
2018
entrez:
12
2
2019
pubmed:
12
2
2019
medline:
12
2
2019
Statut:
epublish
Résumé
The ability of the liver to restore its original volume following tissue loss has been associated with the Hippo-YAP1 pathway, a key controller of organ size. Yes-associated protein 1 (YAP1)-a growth effector usually restrained by Hippo signaling-is believed to be of particular importance; however, its role in liver regeneration remains ill-defined. To explore its function, we knocked down YAP1 prior to standard 70%-hepatectomy (sHx) using a hepatocyte-specific nanoformulation. Knockdown was effective during the major parenchymal growth phase (S-phase/M-phase peaks at 32 hours/48 hours post-sHx). Liver weight gain was completely suppressed by the knockdown at 32 hours, but was reaccelerated toward 48 hours. Likewise, proliferative markers,
Identifiants
pubmed: 30740593
doi: 10.1096/fba.1023
pii: FBA21023
pmc: PMC6351850
doi:
Types de publication
Journal Article
Langues
eng
Pagination
51-61Références
Genes Dev. 2015 Jun 15;29(12):1271-84
pubmed: 26109050
Hepatology. 2018 May;67(5):1823-1841
pubmed: 29149457
Cancer Sci. 2016 Oct;107(10):1380-1389
pubmed: 27420729
J Hepatol. 2016 Jul;65(1):66-74
pubmed: 26948495
Gastroenterology. 2017 Feb;152(3):533-545
pubmed: 28003097
Ann Surg. 2005 Dec;242(6):824-8, discussion 828-9
pubmed: 16327492
J Orthop Res. 2016 Jul;34(7):1121-9
pubmed: 26694636
Am J Physiol Gastrointest Liver Physiol. 2014 Jul 15;307(2):G196-204
pubmed: 24875096
Gastroenterology. 2012 Dec;143(6):1609-1619.e4
pubmed: 22960658
PLoS One. 2015 Jan 30;10(1):e0117522
pubmed: 25635998
Cell Rep. 2015 Mar 17;10(10):1692-1707
pubmed: 25772357
Science. 2015 May 29;348(6238):1024-7
pubmed: 26023140
N Engl J Med. 2007 Apr 12;356(15):1545-59
pubmed: 17429086
Am J Pathol. 2010 Jan;176(1):2-13
pubmed: 20019184
Hepatology. 2017 Sep;66(3):908-921
pubmed: 28437835
J Hepatol. 2018 Aug;69(2):359-367
pubmed: 29758331
Hepatology. 2016 Jul;64(1):232-44
pubmed: 26970079
Gastroenterology. 2015 Feb;148(2):307-23
pubmed: 25224524
J Hepatol. 2005 Jul;43(1):132-41
pubmed: 15893845
Mol Biol Cell. 2016 May 15;27(10):1581-95
pubmed: 27009203
FASEB Bioadv. 2018 Nov 27;1(1):51-61
pubmed: 30740593
EMBO Mol Med. 2017 Jan;9(1):46-60
pubmed: 27940445
Hepatobiliary Pancreat Dis Int. 2012 Jun;11(3):278-84
pubmed: 22672822
Exp Mol Med. 2018 Jan 5;50(1):e423
pubmed: 29303509
Hepatology. 2012 Sep;56(3):1097-107
pubmed: 22886419
PLoS One. 2012;7(4):e35754
pubmed: 22540002
Hepatology. 2016 Dec;64(6):2198-2209
pubmed: 27628483
Curr Biol. 2007 Dec 4;17(23):2054-60
pubmed: 17980593
EMBO J. 2017 Nov 15;36(22):3325-3335
pubmed: 28963395
Mol Cancer Res. 2018 Feb;16(2):197-211
pubmed: 29061667