Molecular layer interneurons shape the spike activity of cerebellar Purkinje cells.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
11 02 2019
Historique:
received: 03 09 2018
accepted: 14 12 2018
entrez: 12 2 2019
pubmed: 12 2 2019
medline: 25 8 2020
Statut: epublish

Résumé

Purkinje cells receive synaptic input from several classes of interneurons. Here, we address the roles of inhibitory molecular layer interneurons in establishing Purkinje cell function in vivo. Using conditional genetics approaches in mice, we compare how the lack of stellate cell versus basket cell GABAergic neurotransmission sculpts the firing properties of Purkinje cells. We take advantage of an inducible Ascl1

Identifiants

pubmed: 30742002
doi: 10.1038/s41598-018-38264-1
pii: 10.1038/s41598-018-38264-1
pmc: PMC6370775
doi:

Substances chimiques

Ascl1 protein, mouse 0
Basic Helix-Loop-Helix Transcription Factors 0
Biomarkers 0
Vesicular Inhibitory Amino Acid Transport Proteins 0
vesicular GABA transporter 0
gamma-Aminobutyric Acid 56-12-2

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1742

Subventions

Organisme : NINDS NIH HHS
ID : F31 NS101891
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS089664
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS100874
Pays : United States
Organisme : NICHD NIH HHS
ID : U54 HD083092
Pays : United States
Organisme : NCRR NIH HHS
ID : C06 RR029965
Pays : United States
Organisme : NINDS NIH HHS
ID : F31 NS092264
Pays : United States
Organisme : NINDS NIH HHS
ID : F31 NS095491
Pays : United States

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Auteurs

Amanda M Brown (AM)

Department of Pathology and Immunology, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas, 77030, USA.
Department of Neuroscience, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas, 77030, USA.
Jan and Dan Duncan Neurological Research Institute of Texas Children's Hospital, 1250 Moursund Street, Suite 1325, Houston, Texas, 77030, USA.

Marife Arancillo (M)

Department of Pathology and Immunology, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas, 77030, USA.
Jan and Dan Duncan Neurological Research Institute of Texas Children's Hospital, 1250 Moursund Street, Suite 1325, Houston, Texas, 77030, USA.

Tao Lin (T)

Department of Pathology and Immunology, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas, 77030, USA.
Jan and Dan Duncan Neurological Research Institute of Texas Children's Hospital, 1250 Moursund Street, Suite 1325, Houston, Texas, 77030, USA.

Daniel R Catt (DR)

Department of Pathology and Immunology, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas, 77030, USA.
Jan and Dan Duncan Neurological Research Institute of Texas Children's Hospital, 1250 Moursund Street, Suite 1325, Houston, Texas, 77030, USA.

Joy Zhou (J)

Department of Pathology and Immunology, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas, 77030, USA.
Jan and Dan Duncan Neurological Research Institute of Texas Children's Hospital, 1250 Moursund Street, Suite 1325, Houston, Texas, 77030, USA.

Elizabeth P Lackey (EP)

Department of Pathology and Immunology, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas, 77030, USA.
Department of Neuroscience, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas, 77030, USA.
Jan and Dan Duncan Neurological Research Institute of Texas Children's Hospital, 1250 Moursund Street, Suite 1325, Houston, Texas, 77030, USA.

Trace L Stay (TL)

Department of Pathology and Immunology, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas, 77030, USA.
Department of Neuroscience, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas, 77030, USA.
Jan and Dan Duncan Neurological Research Institute of Texas Children's Hospital, 1250 Moursund Street, Suite 1325, Houston, Texas, 77030, USA.

Zhongyuan Zuo (Z)

Department of Pathology and Immunology, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas, 77030, USA.
Jan and Dan Duncan Neurological Research Institute of Texas Children's Hospital, 1250 Moursund Street, Suite 1325, Houston, Texas, 77030, USA.

Joshua J White (JJ)

Department of Pathology and Immunology, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas, 77030, USA.
Department of Neuroscience, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas, 77030, USA.
Jan and Dan Duncan Neurological Research Institute of Texas Children's Hospital, 1250 Moursund Street, Suite 1325, Houston, Texas, 77030, USA.

Roy V Sillitoe (RV)

Department of Pathology and Immunology, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas, 77030, USA. sillitoe@bcm.edu.
Department of Neuroscience, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas, 77030, USA. sillitoe@bcm.edu.
Program in Developmental Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas, 77030, USA. sillitoe@bcm.edu.
Jan and Dan Duncan Neurological Research Institute of Texas Children's Hospital, 1250 Moursund Street, Suite 1325, Houston, Texas, 77030, USA. sillitoe@bcm.edu.

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