Estrogen receptor beta expression correlates with proliferation in desmoid tumors.
Adult
Biomarkers, Tumor
/ biosynthesis
Cell Growth Processes
/ physiology
Cyclin D1
/ biosynthesis
Estrogen Receptor beta
/ biosynthesis
Female
Fibromatosis, Aggressive
/ metabolism
Humans
Immunohistochemistry
Male
Neoplasm Recurrence, Local
/ metabolism
Predictive Value of Tests
Retrospective Studies
Tissue Array Analysis
aggressive fibromatosis
biomarkers
cyclins
immunohistochemistry
steroid receptors
Journal
Journal of surgical oncology
ISSN: 1096-9098
Titre abrégé: J Surg Oncol
Pays: United States
ID NLM: 0222643
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
received:
28
01
2019
accepted:
31
01
2019
pubmed:
12
2
2019
medline:
15
5
2019
entrez:
12
2
2019
Statut:
ppublish
Résumé
Estrogen receptor signaling and cyclin D1 have a major role in tumor cell proliferation in breast cancer. Desmoid tumors are rare neoplasms that may respond to endocrine treatment. The present study aimed to investigate the expression levels and the clinical relevance of estrogen receptor beta (ERβ) and cyclin D1 in desmoid tumors. This study consists of 83 patients with a surgically treated desmoid tumor. ERβ and cyclin D1 expression was examined by immunohistochemistry in tissue microarrays. Cyclin A and Ki67 were studied in our previous work. Median ERβ expression was 10.8%. ERβ expression correlated with expression of the proliferation antigens Ki67 (r ERβ and cyclin D1 immunopositivity correlated with high proliferation in desmoid tumors. High ERβ expression might be predictive for postoperative recurrence.
Sections du résumé
BACKGROUND AND OBJECTIVES
OBJECTIVE
Estrogen receptor signaling and cyclin D1 have a major role in tumor cell proliferation in breast cancer. Desmoid tumors are rare neoplasms that may respond to endocrine treatment. The present study aimed to investigate the expression levels and the clinical relevance of estrogen receptor beta (ERβ) and cyclin D1 in desmoid tumors.
METHODS
METHODS
This study consists of 83 patients with a surgically treated desmoid tumor. ERβ and cyclin D1 expression was examined by immunohistochemistry in tissue microarrays. Cyclin A and Ki67 were studied in our previous work.
RESULTS
RESULTS
Median ERβ expression was 10.8%. ERβ expression correlated with expression of the proliferation antigens Ki67 (r
CONCLUSIONS
CONCLUSIONS
ERβ and cyclin D1 immunopositivity correlated with high proliferation in desmoid tumors. High ERβ expression might be predictive for postoperative recurrence.
Substances chimiques
Biomarkers, Tumor
0
CCND1 protein, human
0
ESR2 protein, human
0
Estrogen Receptor beta
0
Cyclin D1
136601-57-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
873-879Subventions
Organisme : Sigrid Juséliuksen Säätiö
Organisme : Finska Läkaresällskapet
Organisme : Medicinska Understödsföreningen Liv och Hälsa
Organisme : Helsinki University Hospital Research funds
Informations de copyright
© 2019 Wiley Periodicals, Inc.