Transforming Growth Factor-β1 Decreases β
Asthma
/ drug therapy
Bronchodilator Agents
/ pharmacology
Carbachol
/ pharmacology
Cyclic AMP
/ metabolism
Cyclic Nucleotide Phosphodiesterases, Type 4
/ metabolism
Cytokines
/ metabolism
Gene Expression Regulation
Humans
Isoproterenol
/ pharmacology
Lung
/ metabolism
Muscle, Smooth
/ drug effects
Myosin Light Chains
/ metabolism
Phosphorylation
RNA, Small Interfering
/ metabolism
Smad2 Protein
/ metabolism
Smad3 Protein
/ metabolism
Trachea
/ drug effects
Transforming Growth Factor beta1
/ metabolism
Transforming Growth Factor beta2
/ agonists
TGF-β1
human airway smooth muscle
relaxation
severe asthma
β-agonists
Journal
American journal of respiratory cell and molecular biology
ISSN: 1535-4989
Titre abrégé: Am J Respir Cell Mol Biol
Pays: United States
ID NLM: 8917225
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
pubmed:
12
2
2019
medline:
9
4
2020
entrez:
12
2
2019
Statut:
ppublish
Résumé
Helper T effector cytokines implicated in asthma modulate the contractility of human airway smooth muscle (HASM) cells. We have reported recently that a profibrotic cytokine, transforming growth factor (TGF)-β1, induces HASM cell shortening and airway hyperresponsiveness. Here, we assessed whether TGF-β1 affects the ability of HASM cells to relax in response to β
Identifiants
pubmed: 30742476
doi: 10.1165/rcmb.2018-0301OC
pmc: PMC6670035
doi:
Substances chimiques
Bronchodilator Agents
0
Cytokines
0
Myosin Light Chains
0
RNA, Small Interfering
0
SMAD2 protein, human
0
SMAD3 protein, human
0
Smad2 Protein
0
Smad3 Protein
0
TGFB1 protein, human
0
TGFB2 protein, human
0
Transforming Growth Factor beta1
0
Transforming Growth Factor beta2
0
Carbachol
8Y164V895Y
Cyclic AMP
E0399OZS9N
Cyclic Nucleotide Phosphodiesterases, Type 4
EC 3.1.4.17
Isoproterenol
L628TT009W
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
209-218Subventions
Organisme : NHLBI NIH HHS
ID : P01 HL114471
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM107094
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008076
Pays : United States
Commentaires et corrections
Type : CommentIn
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