The Nuclear Lamina as an Organizer of Chromosome Architecture.
H3K9me2/3
HP1
LAD
TAD
heterochromatin
lamin
nuclear envelope
nuclear lamina
nuclear periphery
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
08 02 2019
08 02 2019
Historique:
received:
31
12
2018
revised:
04
02
2019
accepted:
06
02
2019
entrez:
13
2
2019
pubmed:
13
2
2019
medline:
13
2
2019
Statut:
epublish
Résumé
The nuclear lamina (NL) is a meshwork of lamins and lamin-associated proteins adjoining the inner side of the nuclear envelope. In early embryonic cells, the NL mainly suppresses background transcription, whereas, in differentiated cell types, its disruption affects gene expression more severely. Normally, the NL serves as a backbone for multiple chromatin anchoring sites, thus shaping the spatial organization of chromosomes in the interphase nucleus. However, upon cell senescence, aging, or in some types of terminally differentiated cells and lamin-associated diseases, the loss of NL-chromatin tethering causes drastic alterations in chromosome architecture. Here, we provide an overview of the recent advances in the field of NL-chromatin interactions, focusing on their impact on chromatin positioning, compaction, repression, and spatial organization.
Identifiants
pubmed: 30744037
pii: cells8020136
doi: 10.3390/cells8020136
pmc: PMC6406483
pii:
doi:
Substances chimiques
Heterochromatin
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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