Inositol Polyphosphate Multikinase (
IPMK
SNP
aging
gender-specific association
inositol phosphates
longevity
moonlighting protein
polymorphism
survival
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
08 02 2019
08 02 2019
Historique:
received:
21
01
2019
revised:
04
02
2019
accepted:
04
02
2019
entrez:
13
2
2019
pubmed:
13
2
2019
medline:
13
2
2019
Statut:
epublish
Résumé
Biogerontological research highlighted a complex and dynamic connection between aging, health and longevity, partially determined by genetic factors. Multifunctional proteins with moonlighting features, by integrating different cellular activities in the space and time, may explain part of this complexity. Inositol Polyphosphate Multikinase (IPMK) is a potential moonlighting protein performing multiple unrelated functions. Initially identified as a key enzyme for inositol phosphates synthesis, small messengers regulating many aspects of cell physiology, IPMK is now implicated in a number of metabolic pathways affecting the aging process. IPMK regulates basic transcription, telomere homeostasis, nutrient-sensing, metabolism and oxidative stress. Here, we tested the hypothesis that the genetic variability of
Identifiants
pubmed: 30744060
pii: genes10020125
doi: 10.3390/genes10020125
pmc: PMC6410091
pii:
doi:
Substances chimiques
Phosphotransferases (Alcohol Group Acceptor)
EC 2.7.1.-
inositol polyphosphate multikinase
EC 2.7.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Medical Research Council
ID : MC_U122680443
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00012/4
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12018/4
Pays : United Kingdom
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Mol Cell. 2018 Jun 7;70(5):936-948.e7
pubmed: 29883610
Age Ageing. 2010 Nov;39(6):674-80
pubmed: 20952373
FEBS Lett. 2000 Feb 18;468(1):28-32
pubmed: 10683435
Ann Hum Genet. 2003 Jan;67(Pt 1):54-62
pubmed: 12556235
J Physiol. 2006 Jul 1;574(Pt 1):125-38
pubmed: 16600998
Trends Biochem Sci. 2017 Mar;42(3):219-231
pubmed: 27876550
Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2306-11
pubmed: 11226235
Science. 2011 Nov 11;334(6057):802-5
pubmed: 22076377
Biogerontology. 2003;4(4):215-20
pubmed: 14501185
Sci Signal. 2013 Apr 02;6(269):ra22
pubmed: 23550211
Biogerontology. 2019 Feb;20(1):17-31
pubmed: 30255223
J Psychiatr Res. 1975 Nov;12(3):189-98
pubmed: 1202204
Cell Metab. 2016 Jun 14;23(6):1022-1033
pubmed: 27304504
J Biol Chem. 2013 Feb 1;288(5):3312-21
pubmed: 23255604
Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):1911-4
pubmed: 15665079
Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14206-11
pubmed: 12391334
JAMA. 1963 Sep 21;185:914-9
pubmed: 14044222
Biochim Biophys Acta. 2009 Oct;1790(10):1067-74
pubmed: 19539012
Sci Rep. 2016 Aug 31;6:32072
pubmed: 27577108
Nat Med. 2015 Dec;21(12):1416-23
pubmed: 26646498
J Clin Invest. 2016 Nov 1;126(11):4273-4288
pubmed: 27701146
Aging Cell. 2014 Jun;13(3):468-77
pubmed: 24341993
Adv Biol Regul. 2017 May;64:9-19
pubmed: 28342784
Aging (Albany NY). 2011 Jan;3(1):55-62
pubmed: 21191145
Science. 2016 May 20;352(6288):986-90
pubmed: 27080106
Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):19938-43
pubmed: 24248338
Rejuvenation Res. 2013 Feb;16(1):28-34
pubmed: 23094790
Mech Ageing Dev. 2017 Jul;165(Pt B):147-155
pubmed: 28390822
Mol Endocrinol. 2014 Jul;28(7):1186-93
pubmed: 24877601
Mol Biosyst. 2009 Apr;5(4):345-50
pubmed: 19396370
Exp Gerontol. 2014 Mar;51:15-27
pubmed: 24365661
Biochem J. 2009 Sep 14;423(1):109-18
pubmed: 19614566
Front Biosci. 2008 Jan 01;13:856-66
pubmed: 17981594
Biochim Biophys Acta. 2016 Sep;1862(9):1766-73
pubmed: 27345265
Front Genet. 2012 Jan 03;2:90
pubmed: 22303384
Gastroenterology. 2015 Jul;149(1):67-78
pubmed: 25865046
Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12783-8
pubmed: 16123124
J Gerontol A Biol Sci Med Sci. 2010 May;65(5):488-94
pubmed: 20154178
JAMA Netw Open. 2018 Aug;1(4):e181670
pubmed: 30294719
Cell Metab. 2011 Feb 2;13(2):215-21
pubmed: 21284988
Gerontology. 2011;57(4):327-34
pubmed: 20558979
Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1391-6
pubmed: 21220345
Biogerontology. 2007 Jun;8(3):283-90
pubmed: 17164982
Biochem Biophys Res Commun. 2012 Apr 27;421(1):1-3
pubmed: 22503973
J Cell Mol Med. 2017 May;21(5):1024-1032
pubmed: 27957792
Bioinformatics. 2005 Jan 15;21(2):263-5
pubmed: 15297300
JAMA Neurol. 2016 Jun 1;73(6):691-7
pubmed: 27088644
Cell. 2010 Jul 9;142(1):9-14
pubmed: 20603007
Science. 2007 Nov 23;318(5854):1299-302
pubmed: 18033884
Mech Ageing Dev. 2016 Mar;154:49-61
pubmed: 26876763
Trends Biochem Sci. 1999 Jan;24(1):8-11
pubmed: 10087914
J Biol Chem. 2012 Nov 2;287(45):38347-55
pubmed: 22992733
Clin Sci (Lond). 2016 Oct 1;130(19):1711-25
pubmed: 27555614
Sci Rep. 2018 Nov 12;8(1):16672
pubmed: 30420721
Ageing Res Rev. 2015 Sep;23(Pt A):90-100
pubmed: 25862945
Adv Biol Regul. 2016 May;61:25-32
pubmed: 26682649
Genes Immun. 2002 Feb;3(1):30-3
pubmed: 11857058
J Cell Sci. 2009 Jun 15;122(Pt 12):1933-7
pubmed: 19494120
Sci Rep. 2016 Feb 25;6:21243
pubmed: 26912274
Sci Adv. 2017 Apr 21;3(4):e1602296
pubmed: 28439546
Curr Opin Struct Biol. 2004 Dec;14(6):663-8
pubmed: 15582389
Biogerontology. 2016 Feb;17(1):109-27
pubmed: 26306600
Aging Cell. 2011 Aug;10(4):686-98
pubmed: 21418511