Genotoxicity of (+)- and (-)-usnic acid in mice.

Animals Anti-Infective Agents / toxicity Benzofurans / toxicity DNA Damage Kidney / metabolism Lichens / metabolism Liver / metabolism Male Mice Oxidative Stress Stereoisomerism
DNA-comets Enantiomers Genotoxcity Mice Oxidative stress Usnic acid

Journal

Mutation research. Genetic toxicology and environmental mutagenesis
ISSN: 1879-3592
Titre abrégé: Mutat Res Genet Toxicol Environ Mutagen
Pays: Netherlands
ID NLM: 101632149

Informations de publication

Date de publication:
Mar 2019
Historique:
received: 03 10 2018
revised: 16 01 2019
accepted: 21 01 2019
entrez: 13 2 2019
pubmed: 13 2 2019
medline: 14 6 2019
Statut: ppublish

Résumé

Usnic acid, which is the most widespread and well-studied secondary lichen compound, has antibacterial and cytotoxic effects. Usnic acid is present in lichens as the (+)- and (-)-enantiomers, which have different biological activities. We used a DNA-comet assay to determine the genotoxic effect of (+)- and (-)-usnic acid in the liver and kidney cells of mice. The genotoxic effect of usnic acid was only observed 1 h after oral administration. Usnic acid doses of 100 and 50 mg/kg resulted in DNA damage in the liver and kidney cells. The genotoxic effect of usnic acid is associated with oxidative stress in cells. There were no significant differences in the effects of (+)- and (-)-enantiomers.

Identifiants

DOI: 10.1016/j.mrgentox.2019.01.010 PMID: 30744810
pubmed: 30744810
pii: S1383-5718(18)30376-0
doi: 10.1016/j.mrgentox.2019.01.010
pii:
doi:

Substances chimiques

Anti-Infective Agents 0
Benzofurans 0
usnic acid 0W584PFJ77

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

36-39

Informations de copyright

Copyright © 2019. Published by Elsevier B.V.

Auteurs

Ilya Prokopiev (I)

Institute for Biological Problems of Cryolithozone, Siberian Brunch of the Russian Academy of Sciences, Lenina 41, Yakutsk 677980, Sakha Republic, Russia. Electronic address: ilya.a.prokopiev@gmai.com.

Galina Filippova (G)

Institute for Biological Problems of Cryolithozone, Siberian Brunch of the Russian Academy of Sciences, Lenina 41, Yakutsk 677980, Sakha Republic, Russia.

Eduard Filippov (E)

Institute for Biological Problems of Cryolithozone, Siberian Brunch of the Russian Academy of Sciences, Lenina 41, Yakutsk 677980, Sakha Republic, Russia.

Ivan Voronov (I)

Institute for Biological Problems of Cryolithozone, Siberian Brunch of the Russian Academy of Sciences, Lenina 41, Yakutsk 677980, Sakha Republic, Russia.

Igor Sleptsov (I)

Institute for Biological Problems of Cryolithozone, Siberian Brunch of the Russian Academy of Sciences, Lenina 41, Yakutsk 677980, Sakha Republic, Russia.

Aliy Zhanataev (A)

Research Zakusov Institute of Pharmacology, Baltiyskaya 8, Moscow 125315, Russia.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Genotoxicity of (+)- and (-)-usnic acid in mice.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Genotoxicity of (+)- and (-)-usnic acid in mice.
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzofuranes › Genotoxicity of (+)- and (-)-usnic acid in mice.
questionsmedicales.fr › Phénomènes génétiques › Altération de l'ADN › Genotoxicity of (+)- and (-)-usnic acid in mice.
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › Genotoxicity of (+)- and (-)-usnic acid in mice.
questionsmedicales.fr › Stades d'organismes › Lichens › Genotoxicity of (+)- and (-)-usnic acid in mice.
questionsmedicales.fr › Système digestif › Foie › Genotoxicity of (+)- and (-)-usnic acid in mice.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Genotoxicity of (+)- and (-)-usnic acid in mice.
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Genotoxicity of (+)- and (-)-usnic acid in mice.
questionsmedicales.fr › Phénomènes chimiques › Phénomènes de chimie organique › Isomérie › Stéréoisomérie › Genotoxicity of (+)- and (-)-usnic acid in mice.