Circadian rhythms of cardiovascular autonomic function: Physiology and clinical implications in neurodegenerative diseases.
Alzheimer's disease
Autonomic nervous system
Circadian rhythms
Neurodegenerative diseases
Parkinson's disease
Suprachiasmatic nucleus
Journal
Autonomic neuroscience : basic & clinical
ISSN: 1872-7484
Titre abrégé: Auton Neurosci
Pays: Netherlands
ID NLM: 100909359
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
30
11
2018
revised:
31
01
2019
accepted:
31
01
2019
entrez:
13
2
2019
pubmed:
13
2
2019
medline:
13
3
2020
Statut:
ppublish
Résumé
Circadian rhythms of blood pressure and heart rate are regulated by a biological clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus, which modulates the autonomic nervous system activity directed to the heart and blood vessels. Humoral mediators released with periodicity induced by the SCN as well as sleep are also important factors. Disruption of physiological cardiovascular circadian rhythms has important clinical implications, as it is associated with increased morbidity and mortality. In this review, firstly we will give an overview on the neuroanatomic and physiologic aspects of cardiovascular circadian rhythms. Secondly we will examine how to assess them in clinical practice. Finally we will discuss certain neurodegenerative diseases in which there is an alteration of these rhythms, such as Parkinson's disease and Alzheimer's disease.
Identifiants
pubmed: 30744907
pii: S1566-0702(18)30305-9
doi: 10.1016/j.autneu.2019.01.009
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
91-101Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.