Epidemiology of human respiratory viruses in children with acute respiratory tract infection in a 3-year hospital-based survey in Northern Italy.
Adolescent
Child
Child, Preschool
Coinfection
/ epidemiology
Diagnostic Tests, Routine
/ methods
Female
Hospitals
Humans
Incidence
Infant
Infant, Newborn
Italy
/ epidemiology
Male
Microbiological Techniques
/ methods
Respiratory Tract Infections
/ epidemiology
Surveys and Questionnaires
Virus Diseases
/ epidemiology
Viruses
/ classification
Acute respiratory tract infections
Epidemiology
Laboratory diagnosis
Molecular assays
Respiratory viruses
Virus isolation in cell culture
Journal
Diagnostic microbiology and infectious disease
ISSN: 1879-0070
Titre abrégé: Diagn Microbiol Infect Dis
Pays: United States
ID NLM: 8305899
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
12
07
2018
revised:
08
01
2019
accepted:
09
01
2019
pubmed:
13
2
2019
medline:
8
11
2019
entrez:
13
2
2019
Statut:
ppublish
Résumé
Acute respiratory tract infections (ARTIs) are among the leading causes of morbidity and mortality in children. The viral etiology of ARTIs was investigated over 3 years (October 2012-September 2015) in 2575 children in Parma, Italy, using indirect immunofluorescent staining of respiratory samples for viral antigens, cell culture, and molecular assays. Respiratory viruses were detected in 1299 cases (50.44%); 1037 (79.83%) were single infections and 262 (20.17%) mixed infections. The highest infection incidence was in children aged >6 months to ≤3 years (57.36%). Human respiratory syncytial virus (27.12%) and human adenovirus (23.58%) were the most common viruses identified. The virus detection rate decreased significantly between the first and third epidemic season (53.9% vs. 43.05%, P < 0.0001). The simultaneous use of different diagnostic tools allowed us to identify a putative viral etiology in half the children examined and to provide an estimate of the epidemiology and seasonality of respiratory viruses associated with ARTIs.
Identifiants
pubmed: 30745224
pii: S0732-8893(19)30053-7
doi: 10.1016/j.diagmicrobio.2019.01.008
pmc: PMC7126416
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
260-267Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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