Myelofibrosis osteoclasts are clonal and functionally impaired.
Journal
Blood
ISSN: 1528-0020
Titre abrégé: Blood
Pays: United States
ID NLM: 7603509
Informations de publication
Date de publication:
23 05 2019
23 05 2019
Historique:
received:
05
10
2018
accepted:
06
02
2019
pubmed:
13
2
2019
medline:
24
12
2019
entrez:
13
2
2019
Statut:
ppublish
Résumé
Bone marrow (BM) sclerosis is commonly found in patients with late-stage myelofibrosis (MF). Because osteoclasts (OCs) and osteoblasts play a key role in bone remodeling, and MF monocytes, the OC precursors, are derived from the neoplastic clone, we wondered whether decreased OC numbers or impairment in their osteolytic function affects the development of osteosclerosis. Analysis of BM biopsies from 50 MF patients showed increased numbers of multinucleated tartrate-resistant acid phosphatase (TRAP)/cathepsin K
Identifiants
pubmed: 30745304
pii: S0006-4971(20)42539-X
doi: 10.1182/blood-2018-10-878926
pmc: PMC6533604
doi:
Substances chimiques
CALR protein, human
0
Calreticulin
0
JAK2 protein, human
EC 2.7.10.2
Janus Kinase 2
EC 2.7.10.2
ACP5 protein, human
EC 3.1.3.2
Tartrate-Resistant Acid Phosphatase
EC 3.1.3.2
CTSK protein, human
EC 3.4.22.38
Cathepsin K
EC 3.4.22.38
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2320-2324Subventions
Organisme : NCI NIH HHS
ID : P30 CA016672
Pays : United States
Informations de copyright
© 2019 by The American Society of Hematology.
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