Activity of a Long-Acting Injectable Bedaquiline Formulation in a Paucibacillary Mouse Model of Latent Tuberculosis Infection.

Administration, Oral Animals Antitubercular Agents / administration & dosage Diarylquinolines / administration & dosage Disease Models, Animal Female Injections, Intramuscular Latent Tuberculosis / drug therapy Male Mice Mice, Inbred BALB C Microbial Sensitivity Tests Mycobacterium tuberculosis / drug effects
BALB/c mice bedaquiline latent tuberculosis infection long-acting injectable

Journal

Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061

Informations de publication

Date de publication:
04 2019
Historique:
received: 08 01 2019
accepted: 05 02 2019
pubmed: 13 2 2019
medline: 11 3 2020
entrez: 13 2 2019
Statut: epublish

Résumé

The potent antituberculosis activity and long half-life of bedaquiline make it an attractive candidate for use in long-acting/extended-release formulations for the treatment of latent tuberculosis infection (LTBI). Our objective was to evaluate a long-acting injectable (LAI) bedaquiline formulation in a validated paucibacillary mouse model of LTBI. Following immunization with

Identifiants

DOI: 10.1128/AAC.00007-19 PMID: 30745396 PMC: PMC6437534
pubmed: 30745396
pii: AAC.00007-19
doi: 10.1128/AAC.00007-19
pmc: PMC6437534
pii:
doi:

Substances chimiques

Antitubercular Agents 0
Diarylquinolines 0
bedaquiline 78846I289Y

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2019 Kaushik et al.

Références

Am J Respir Crit Care Med. 2009 Dec 1;180(11):1151-7
pubmed: 19729664
Infect Immun. 2004 Feb;72(2):1065-71
pubmed: 14742554
J Int AIDS Soc. 2016 May 30;19(1):20875
pubmed: 27247202
N Engl J Med. 2014 Aug 21;371(8):723-32
pubmed: 25140958
Microbiol Spectr. 2017 Jun;5(3):
pubmed: 28643624
Am Rev Respir Dis. 1967 Jun;95(6):998-1004
pubmed: 4961042
PLoS Med. 2016 Oct 25;13(10):e1002152
pubmed: 27780211
Arch Pharm Res. 2013 Jun;36(6):651-9
pubmed: 23543652
Lancet. 2015 May 2;385(9979):1799-1801
pubmed: 25814376
Int J Tuberc Lung Dis. 2018 Aug 1;22(8):937-944
pubmed: 29991405
Eur Respir J. 2017 May 21;49(5):
pubmed: 28529205
J Antimicrob Chemother. 2017 Feb;72(2):455-461
pubmed: 27798204
Antimicrob Agents Chemother. 2012 Jun;56(6):3271-6
pubmed: 22391540
Antimicrob Agents Chemother. 2011 Dec;55(12):5485-92
pubmed: 21930883
Ann Intern Med. 2014 Sep 16;161(6):419-28
pubmed: 25111745
Lancet. 2017 Sep 23;390(10101):1499-1510
pubmed: 28750935
Antimicrob Agents Chemother. 2014;58(4):2316-21
pubmed: 24492372
AIDS Behav. 2018 Jan;22(1):133-145
pubmed: 29052018
Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13853-8
pubmed: 11095745
PLoS One. 2011 Mar 03;6(3):e17556
pubmed: 21408613
J Med Microbiol. 1972 May;5(2):165-75
pubmed: 4338078
Antimicrob Agents Chemother. 2009 Oct;53(10):4178-84
pubmed: 19620331
Microbes Infect. 2005 May;7(5-6):947-54
pubmed: 15919223
BMC Infect Dis. 2017 Apr 11;17(1):265
pubmed: 28399802
BMC Infect Dis. 2016 Jun 08;16:257
pubmed: 27268103
Clin Microbiol Infect. 2017 Mar;23(3):147-153
pubmed: 27592087
PLoS Med. 2007 Dec;4(12):e344
pubmed: 18092886
Am J Respir Crit Care Med. 2011 Sep 15;184(6):732-7
pubmed: 21659613
Am J Respir Crit Care Med. 2009 Sep 15;180(6):553-7
pubmed: 19590024
Science. 2005 Jan 14;307(5707):223-7
pubmed: 15591164
Int J Health Plann Manage. 2018 Apr;33(2):e416-e433
pubmed: 29431235
Antimicrob Agents Chemother. 1973 Aug;4(2):94-104
pubmed: 4208508
Antimicrob Agents Chemother. 2015 Oct;59(10):6561-7
pubmed: 26259792
AIDS Behav. 2018 Apr;22(4):1217-1227
pubmed: 28707025
J Psychosoc Nurs Ment Health Serv. 2013 Mar;51(3):13-8
pubmed: 23547305
Am J Respir Crit Care Med. 2005 Dec 1;172(11):1452-6
pubmed: 16151038
Antimicrob Agents Chemother. 2012 Mar;56(3):1444-51
pubmed: 22155815
Int J Tuberc Lung Dis. 2018 Feb 1;22(2):125-132
pubmed: 29506608
PLoS One. 2017 Aug 21;12(8):e0183521
pubmed: 28827821
Antimicrob Agents Chemother. 2016 Jul 22;60(8):4590-9
pubmed: 27185800
ERJ Open Res. 2018 Mar 23;4(1):
pubmed: 29577042
Cochrane Database Syst Rev. 2013 Oct 26;(10):CD004317
pubmed: 24163097
Nat Commun. 2018 Feb 6;9(1):443
pubmed: 29402886
Curr Opin HIV AIDS. 2015 Jul;10(4):239-45
pubmed: 26049948
Curr Opin HIV AIDS. 2015 Jul;10(4):233-8
pubmed: 26049947
Clin Pharmacokinet. 2018 Feb;57(2):255-266
pubmed: 28540638

Auteurs

Amit Kaushik (A)

Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Nicole C Ammerman (NC)

Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
ORCID: 0000-0001-9359-9144

Sandeep Tyagi (S)

Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Vikram Saini (V)

Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Iwan Vervoort (I)

Janssen R&D, Beerse, Belgium.

Sophie Lachau-Durand (S)

Janssen R&D, Beerse, Belgium.

Eric Nuermberger (E)

Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA enuermb@jhmi.edu.

Koen Andries (K)

Janssen R&D, Beerse, Belgium.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Administration par voie orale › Activity of a Long-Acting Injectable...
questionsmedicales.fr › Eucaryotes › Animaux › Activity of a Long-Acting Injectable...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Antituberculeux › Activity of a Long-Acting Injectable...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinoléines › Diarylquinoléines › Activity of a Long-Acting Injectable...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Activity of a Long-Acting Injectable...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Injections › Injections musculaires › Activity of a Long-Acting Injectable...
questionsmedicales.fr › Infection › Infection latente › Tuberculose latente › Activity of a Long-Acting Injectable...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Activity of a Long-Acting Injectable...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée BALB C › Activity of a Long-Acting Injectable...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Activity of a Long-Acting Injectable...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets asporogènes à Gram positif › Bâtonnets asporogènes réguliers à Gram positif › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis › Activity of a Long-Acting Injectable...