Upper Airway Cell Transcriptomics Identify a Major New Immunological Phenotype with Strong Clinical Correlates in Young Children with Acute Wheezing.

Adolescent Asthma / genetics Case-Control Studies Child Child, Preschool Cluster Analysis Female Gene Regulatory Networks Humans Infant Infant, Newborn Interferon Regulatory Factor-7 / genetics Male Phenotype Respiratory Sounds / genetics Respiratory Tract Infections / complications Transcriptome

Journal

Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R

Informations de publication

Date de publication:
15 03 2019
Historique:
received: 07 02 2018
accepted: 08 01 2019
pubmed: 13 2 2019
medline: 11 1 2020
entrez: 13 2 2019
Statut: ppublish

Résumé

Asthma exacerbations are triggered by rhinovirus infections. We employed a systems biology approach to delineate upper-airway gene network patterns underlying asthma exacerbation phenotypes in children. Cluster analysis unveiled distinct IRF7

Identifiants

DOI: 10.4049/jimmunol.1800178 PMID: 30745463
pubmed: 30745463
pii: jimmunol.1800178
doi: 10.4049/jimmunol.1800178
doi:

Substances chimiques

IRF7 protein, human 0
Interferon Regulatory Factor-7 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1845-1858

Informations de copyright

Copyright © 2019 by The American Association of Immunologists, Inc.

Auteurs

Siew-Kim Khoo (SK)

Division of Cardiovascular and Respiratory Sciences, The University of Western Australia, Perth, Western Australia 6009, Australia.
Telethon Kids Institute, The University of Western Australia, Perth, Western Australia 6008, Australia.

James Read (J)

Telethon Kids Institute, The University of Western Australia, Perth, Western Australia 6008, Australia.

Kimberley Franks (K)

Division of Cardiovascular and Respiratory Sciences, The University of Western Australia, Perth, Western Australia 6009, Australia.
Telethon Kids Institute, The University of Western Australia, Perth, Western Australia 6008, Australia.

Guicheng Zhang (G)

Division of Cardiovascular and Respiratory Sciences, The University of Western Australia, Perth, Western Australia 6009, Australia.
School of Public Health, Curtin University, Perth, Western Australia 6102, Australia.
Centre for Genetic Origins of Health and Disease, The University of Western Australia, Perth, Western Australia 6009, Australia and Curtin University, Perth, Western Australia 6102, Australia.
ORCID: 0000-0001-9888-5385

Joelene Bizzintino (J)

Division of Cardiovascular and Respiratory Sciences, The University of Western Australia, Perth, Western Australia 6009, Australia.
Telethon Kids Institute, The University of Western Australia, Perth, Western Australia 6008, Australia.

Laura Coleman (L)

Division of Cardiovascular and Respiratory Sciences, The University of Western Australia, Perth, Western Australia 6009, Australia.
Telethon Kids Institute, The University of Western Australia, Perth, Western Australia 6008, Australia.
ORCID: 0000-0002-5356-4577

Christopher McCrae (C)

Respiratory Inflammation and Autoimmunity, IMED Biotech Unit, AstraZeneca, Gothenburg, 431 53 Mölndal, Sweden.

Lisa Öberg (L)

Respiratory Inflammation and Autoimmunity, IMED Biotech Unit, AstraZeneca, Gothenburg, 431 53 Mölndal, Sweden.
ORCID: 0000-0001-7127-1711

Niamh M Troy (NM)

Telethon Kids Institute, The University of Western Australia, Perth, Western Australia 6008, Australia.

Franciska Prastanti (F)

Division of Cardiovascular and Respiratory Sciences, The University of Western Australia, Perth, Western Australia 6009, Australia.
Telethon Kids Institute, The University of Western Australia, Perth, Western Australia 6008, Australia.

Janet Everard (J)

Division of Cardiovascular and Respiratory Sciences, The University of Western Australia, Perth, Western Australia 6009, Australia.
Telethon Kids Institute, The University of Western Australia, Perth, Western Australia 6008, Australia.

Stephen Oo (S)

Division of Paediatrics, School of Medicine, The University of Western Australia, Perth, Western Australia 6009, Australia.
ORCID: 0000-0002-3471-6993

Meredith L Borland (ML)

Division of Paediatrics, School of Medicine, The University of Western Australia, Perth, Western Australia 6009, Australia.
Perth Children's Hospital, Perth, Western Australia 6009, Australia; and.
Division of Emergency Medicine, School of Medicine, The University of Western Australia, Perth, Western Australia 6009, Australia.

Rose A Maciewicz (RA)

Respiratory Inflammation and Autoimmunity, IMED Biotech Unit, AstraZeneca, Gothenburg, 431 53 Mölndal, Sweden.

Peter N Le Souëf (PN)

Telethon Kids Institute, The University of Western Australia, Perth, Western Australia 6008, Australia.
Division of Paediatrics, School of Medicine, The University of Western Australia, Perth, Western Australia 6009, Australia.
ORCID: 0000-0003-0930-1654

Ingrid A Laing (IA)

Division of Cardiovascular and Respiratory Sciences, The University of Western Australia, Perth, Western Australia 6009, Australia.
Telethon Kids Institute, The University of Western Australia, Perth, Western Australia 6008, Australia.

Anthony Bosco (A)

Telethon Kids Institute, The University of Western Australia, Perth, Western Australia 6008, Australia; Anthony.Bosco@telethonkids.org.au.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Upper Airway Cell Transcriptomics Identify a...
questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Hypersensibilité immédiate › Hypersensibilité respiratoire › Asthme › Upper Airway Cell Transcriptomics Identify a...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Upper Airway Cell Transcriptomics Identify a...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Upper Airway Cell Transcriptomics Identify a...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Enfant d'âge préscolaire › Upper Airway Cell Transcriptomics Identify a...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de regroupements › Upper Airway Cell Transcriptomics Identify a...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Séquences d'acides nucléiques régulatrices › Réseaux de régulation génique › Upper Airway Cell Transcriptomics Identify a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Upper Airway Cell Transcriptomics Identify a...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Upper Airway Cell Transcriptomics Identify a...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Nouveau-né › Upper Airway Cell Transcriptomics Identify a...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de régulation d'interféron › Facteur-7 de régulation d'interféron › Upper Airway Cell Transcriptomics Identify a...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Upper Airway Cell Transcriptomics Identify a...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques respiratoires › Bruits respiratoires › Upper Airway Cell Transcriptomics Identify a...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Upper Airway Cell Transcriptomics Identify a...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › Upper Airway Cell Transcriptomics Identify a...