Genetics of obsessive-compulsive disorder.
Candidate gene study
family study
genetics
genome-wide association study
linkage study
obsessive-compulsive disorder
twin study
Journal
Indian journal of psychiatry
ISSN: 0019-5545
Titre abrégé: Indian J Psychiatry
Pays: India
ID NLM: 0013255
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
entrez:
13
2
2019
pubmed:
13
2
2019
medline:
13
2
2019
Statut:
ppublish
Résumé
Obsessive-compulsive disorder (OCD) has been seen to run in families and genetics help to understand its heritability. In this review, we summarize older studies which focused on establishing the familial nature of OCD, including its various dimensions of symptoms, and we focus on recent findings from studies using both the candidate gene approach and genome-wide association study (GWAS) approach. The family studies and twin studies establish the heritability of OCD. Candidate gene approaches have implicated genes in the serotonergic, glutamatergic, and dopaminergic pathways. GWAS has not produced significant results possibly due to the small sample size. Newer techniques such as gene expression studies in brain tissue, stem cell technology, and epigenetic studies may shed more light on the complex genetic basis of OCD.
Identifiants
pubmed: 30745675
doi: 10.4103/psychiatry.IndianJPsychiatry_518_18
pii: IJPsy-61-37
pmc: PMC6343406
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
S37-S42Déclaration de conflit d'intérêts
There are no conflicts of interest.
Références
Nat Genet. 2013 Oct;45(10):1150-9
pubmed: 23974872
Psychol Med. 2001 Apr;31(3):481-7
pubmed: 11305856
Arch Gen Psychiatry. 1992 May;49(5):362-8
pubmed: 1586271
J Clin Psychiatry. 1994 Mar;55 Suppl:5-10
pubmed: 8077177
Am J Med Genet B Neuropsychiatr Genet. 2005 Jul 5;136B(1):92-7
pubmed: 15892140
Am J Med Genet B Neuropsychiatr Genet. 2011 Jun;156B(4):472-7
pubmed: 21445956
Neuropsychopharmacology. 2015 Jul;40(8):1866-76
pubmed: 25662837
J Affect Disord. 2015 Nov 1;186:284-92
pubmed: 26254621
Psychopathology. 2011;44(2):83-9
pubmed: 21196809
Am J Psychiatry. 2007 Mar;164(3):493-9
pubmed: 17329475
Nature. 2007 Aug 23;448(7156):894-900
pubmed: 17713528
Curr Psychiatry Rep. 2009 Aug;11(4):277-82
pubmed: 19635235
Cochrane Database Syst Rev. 2008 Jan 23;(1):CD001765
pubmed: 18253995
Br J Psychol. 1964 Aug;55:265-9
pubmed: 14197794
Pharmacol Ther. 2011 Dec;132(3):314-32
pubmed: 21963369
Proc R Soc Med. 1936 Feb;29(4):325-36
pubmed: 19990606
JAMA Psychiatry. 2013 Jul;70(7):709-17
pubmed: 23699935
Mol Psychiatry. 2006 Aug;11(8):763-70
pubmed: 16755275
Am J Med Genet B Neuropsychiatr Genet. 2009 Jul 5;150B(5):710-20
pubmed: 19051237
Pharmacol Biochem Behav. 2012 Feb;100(4):726-35
pubmed: 22024159
Am J Hum Genet. 2004 Sep;75(3):508-13
pubmed: 15272418
Int J Clin Exp Med. 2015 Mar 15;8(3):4606-10
pubmed: 26064393
Neurosci Lett. 2014 Sep 19;580:100-3
pubmed: 25093702
Transl Psychiatry. 2016 Feb 09;6:e731
pubmed: 26859814
Arch Gen Psychiatry. 2011 Jun;68(6):637-44
pubmed: 21646580
Science. 2008 Nov 7;322(5903):881-8
pubmed: 18988837
JAMA Psychiatry. 2014 Feb;71(2):182-9
pubmed: 24369376
Am J Med Genet B Neuropsychiatr Genet. 2016 Oct;171(7):938-47
pubmed: 26919823
Dialogues Clin Neurosci. 2010;12(2):149-63
pubmed: 20623920
Psychiatry Res. 2013 Sep 30;209(2):202-6
pubmed: 23676614
Neuropsychiatr Dis Treat. 2015 Apr 01;11:897-905
pubmed: 25897225
J Child Psychol Psychiatry. 2003 Oct;44(7):945-60
pubmed: 14531577
Br J Psychiatry. 2009 Oct;195(4):301-7
pubmed: 19794197
J Am Acad Child Adolesc Psychiatry. 2014 Aug;53(8):910-9
pubmed: 25062598
Mol Psychiatry. 2018 May;23(5):1181-1188
pubmed: 28761083
Am J Psychiatry. 2006 Nov;163(11):1986-92
pubmed: 17074951
Arch Gen Psychiatry. 2000 Apr;57(4):358-63
pubmed: 10768697
Transl Psychiatry. 2016 Mar 29;6:e764
pubmed: 27023170
Arch Gen Psychiatry. 2009 Apr;66(4):408-16
pubmed: 19349310
Mol Psychiatry. 2013 Jul;18(7):788-98
pubmed: 22889921
Mol Psychiatry. 2013 Jul;18(7):799-805
pubmed: 22665263
Mol Psychiatry. 2015 Mar;20(3):337-44
pubmed: 24821223
Compr Psychiatry. 2018 Apr;82:1-6
pubmed: 29331882
Am J Med Genet. 2002 Jul 8;114(5):541-52
pubmed: 12116192
Twin Res Hum Genet. 2005 Oct;8(5):450-8
pubmed: 16212834
Transl Psychiatry. 2013 May 21;3:e259
pubmed: 23695234
Compr Psychiatry. 2014 Oct;55(7):1520-5
pubmed: 25088515
Biol Psychiatry. 2000 Aug 15;48(4):287-93
pubmed: 10960159
Am J Med Genet B Neuropsychiatr Genet. 2009 Sep 5;150B(6):886-92
pubmed: 19152386
Am J Med Genet B Neuropsychiatr Genet. 2005 Apr 5;134B(1):13-9
pubmed: 15635694
Am J Med Genet B Neuropsychiatr Genet. 2007 Dec 5;144B(8):1027-33
pubmed: 17894418
J Mol Neurosci. 2013 Jun;50(2):353-9
pubmed: 23564280
Psychol Med. 2007 Jan;37(1):39-48
pubmed: 16999878
Prog Neuropsychopharmacol Biol Psychiatry. 2013 Mar 5;41:18-23
pubmed: 23127570
Expert Rev Neurother. 2010 Feb;10(2):275-90
pubmed: 20136383
Proc Natl Acad Sci U S A. 2017 May 30;114(22):5719-5724
pubmed: 28507136
Am J Med Genet B Neuropsychiatr Genet. 2016 Apr;171B(3):325-32
pubmed: 26616111
Psychiatry Res. 2016 May 30;239:315-9
pubmed: 27058157
Arch Gen Psychiatry. 2004 Jun;61(6):608-16
pubmed: 15184240
Indian J Psychiatry. 2017 Jan-Mar;59(1):56-62
pubmed: 28529361
Behav Genet. 2015 Mar;45(2):255-61
pubmed: 25564228
Biol Psychiatry. 2001 Oct 15;50(8):559-65
pubmed: 11690590
Science. 2013 Jun 7;340(6137):1243-6
pubmed: 23744950
Am J Psychiatry. 1995 Jan;152(1):76-84
pubmed: 7802125
Science. 2004 Oct 22;306(5696):636-40
pubmed: 15499007
Neuropharmacology. 2008 Nov;55(6):932-60
pubmed: 18824000