Solid Dispersion of Kaempferol: Formulation Development, Characterization, and Oral Bioavailability Assessment.

Administration, Oral Animals Area Under Curve Biological Availability Calorimetry, Differential Scanning Kaempferols / chemistry Male Microscopy, Electron, Scanning Poloxamer / chemistry Rats Solubility Spectroscopy, Fourier Transform Infrared / methods
Poloxamer 407 bioavailability dissolution kaempferol solid dispersion

Journal

AAPS PharmSciTech
ISSN: 1530-9932
Titre abrégé: AAPS PharmSciTech
Pays: United States
ID NLM: 100960111

Informations de publication

Date de publication:
11 Feb 2019
Historique:
received: 29 11 2018
accepted: 22 01 2019
entrez: 13 2 2019
pubmed: 13 2 2019
medline: 6 4 2019
Statut: epublish

Résumé

Kaempferol (KPF), an important flavonoid, has been reported to exert antioxidant, anti-inflammatory, and anticancer activity. However, this compound has low water solubility and hence poor oral bioavailability. This work aims to prepare a solid dispersion (SD) of KPF using Poloxamer 407 in order to improve the water solubility, dissolution rate, and pharmacokinetic properties KPF. After optimization, SDs were prepared at a 1:5 weight ratio of KPF:carrier using the solvent method (SD

Identifiants

DOI: 10.1208/s12249-019-1318-y PMID: 30746582
pubmed: 30746582
doi: 10.1208/s12249-019-1318-y
pii: 10.1208/s12249-019-1318-y
doi:

Substances chimiques

Kaempferols 0
Poloxamer 106392-12-5
kaempferol 731P2LE49E

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

106

Auteurs

Mariana Colombo (M)

Laboratório de Desenvolvimento Galênico, Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Avenida Ipiranga, 2752-607, Porto Alegre, RS, 90610-000, Brazil.

Gabriela de Lima Melchiades (G)

Laboratório de Desenvolvimento Galênico, Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Avenida Ipiranga, 2752-607, Porto Alegre, RS, 90610-000, Brazil.

Luana Roberta Michels (LR)

Laboratório de Desenvolvimento Galênico, Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Avenida Ipiranga, 2752-607, Porto Alegre, RS, 90610-000, Brazil.

Fabrício Figueiró (F)

Programa de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Avenida Ramiro Barcelos, 2600 Anexo, Porto Alegre, RS, 90035-003, Brazil.
Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Avenida Ramiro Barcelos, 2600 Anexo, Porto Alegre, RS, 90035-003, Brazil.

Valquiria Linck Bassani (VL)

Laboratório de Desenvolvimento Galênico, Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Avenida Ipiranga, 2752-607, Porto Alegre, RS, 90610-000, Brazil.

Helder Ferreira Teixeira (HF)

Laboratório de Desenvolvimento Galênico, Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Avenida Ipiranga, 2752-607, Porto Alegre, RS, 90610-000, Brazil.

Letícia Scherer Koester (LS)

Laboratório de Desenvolvimento Galênico, Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Avenida Ipiranga, 2752-607, Porto Alegre, RS, 90610-000, Brazil. leticia.koester@ufrgs.br.

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Classifications MeSH

questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Administration par voie orale › Solid Dispersion of Kaempferol: Formulation...
questionsmedicales.fr › Eucaryotes › Animaux › Solid Dispersion of Kaempferol: Formulation...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Aire sous la courbe › Solid Dispersion of Kaempferol: Formulation...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Biodisponibilité › Solid Dispersion of Kaempferol: Formulation...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse thermique différentielle › Calorimétrie différentielle à balayage › Solid Dispersion of Kaempferol: Formulation...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › Flavonoïdes › Flavonols › Kaempférols › Solid Dispersion of Kaempferol: Formulation...
questionsmedicales.fr › Techniques d'investigation › Microscopie électronique › Microscopie électronique à balayage › Solid Dispersion of Kaempferol: Formulation...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Polyéthylène glycols › Poloxamère › Solid Dispersion of Kaempferol: Formulation...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Solid Dispersion of Kaempferol: Formulation...
questionsmedicales.fr › Phénomènes chimiques › Solubilité › Solid Dispersion of Kaempferol: Formulation...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectrophotométrie › Spectrophotométrie IR › Spectroscopie infrarouge à transformée de Fourier › Solid Dispersion of Kaempferol: Formulation...